ArticleBiomicrofluidics2017
Rapid isolation of blood plasma using a cascaded inertial microfluidic device.
Article in Biomicrofluidics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Intelligent Microfluidics for Plasma Separation: Integrating Computational Fluid Dynamics and Machine Learning for Optimized Microchannel Design.Biosensors · 2025Article
- Looping Flexible Fluoropolymer Microcapillary Film Extends Analysis Times for Vertical Microfluidic Blood Testing.Sensors (Basel, Switzerland) · 2024Article
- 3D Printed Devices for the Separation of Blood Plasma from Capillary Samples.Micromachines · 2024Article
- Dean vortex-enhanced blood plasma separation in self-driven spiral microchannel flow with cross-flow microfilters.Biomicrofluidics · 2024Article
- Compact Point-of-Care Device for Self-Administered HIV Viral Load Tests from Whole Blood.ACS sensors · 2023Article
- Blood component separation in straight microfluidic channels.Biomicrofluidics · 2023Article
- Influence of storage and buffer composition on the mechanical behavior of flowing red blood cells.Biophysical journal · 2023Article
- Sensitive and Quantitative Point-of-Care HIV Viral Load Quantification from Blood Using a Power-Free Plasma Separation and Portable Magnetofluidic Polymerase Chain Reaction Instrument.Analytical chemistry · 2023Article
- Advances in Microfluidics for Single Red Blood Cell Analysis.Biosensors · 2023Review
- Microfluidics geometries involved in effective blood plasma separation.Microfluidics and nanofluidics · 2022Review
- Blood Plasma Self-Separation Technologies during the Self-Driven Flow in Microfluidic Platforms.Bioengineering (Basel, Switzerland) · 2021Review
- Microsphere-Based Microfluidic Device for Plasma Separation and Potential Biochemistry Analysis Applications.Micromachines · 2021Article
- Enhanced Separation Efficiency and Purity of Circulating Tumor Cells Based on the Combined Effects of Double Sheath Fluids and Inertial Focusing.Frontiers in bioengineering and biotechnology · 2021Article
- Plasma Isolation in a Syringe by Conformal Integration of Inertial Microfluidics.Annals of biomedical engineering · 2021Article
- Spiral microfluidic devices for cell separation and sorting in bioprocesses.Biomicrofluidics · 2019Review
- Progress of Inertial Microfluidics in Principle and Application.Sensors (Basel, Switzerland) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Blood, saliva, mucus, sweat, sputum, and other biological fluids are often hindered in their ability to be used in point-of-care (POC) diagnostics because their assays require some form of off-site sample pre-preparation to effectively separate biomarkers from larger components such as cells. The rapid isolation, identification, and quantification of proteins and other small molecules circulating in the blood plasma from larger interfering molecules are therefore particularly important factors for optical blood diagnostic tests, in particular, when using optical approaches that incur spectroscopic interference from hemoglobin-rich red blood cells (RBCs). In this work, a sequential spiral polydimethylsiloxane (PDMS) microfluidic device for rapid (∼1 min) on-chip blood cell separation is presented. The chip utilizes Dean-force induced migration via two 5-loop Archimedean spirals in series. The chip was characterized in its ability to filter solutions containing fluorescent beads and silver nanoparticles and further using blood solutions doped with a fluorescent protein. Through these experiments, both cellular and small molecule behaviors in the chip were assessed. The results exhibit an average RBC separation efficiency of ∼99% at a rate of 5.2 × 10
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.