Evidence map›Paper›PMID 28405233›Full record

ArticleBeilstein journal of organic chemistry2017

Novel β-cyclodextrin-eosin conjugates.

Gábor Benkovics, Damien Afonso, András Darcsi, Szabolcs Béni, Sabrina Conoci, Éva Fenyvesi, Lajos Szente, Milo Malanga, Salvatore Sortino

Abstract read
In one paragraph

Article in Beilstein journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Acta pharmaceutica Sinica. B · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gábor BenkovicsCycloLab, Cyclodextrin R&D Ltd, Budapest, H-1097 Illatos út 7, Hungary; Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavová 8, 128 43, Prague 2, Czech Republic.
Damien AfonsoLaboratory of Photochemistry, Department of Drug Sciences, University of Catania, I-95125 Viale A. Doria 6, Italy.
András DarcsiDepartment of Pharmacognosy, Semmelweis University, H-1085 Üllői út 26, Hungary.
Szabolcs BéniDepartment of Pharmacognosy, Semmelweis University, H-1085 Üllői út 26, Hungary.
Sabrina ConociSTMicroelectronics, Stradale Primosole 50, I-95121, Catania, Italy.
Éva FenyvesiCycloLab, Cyclodextrin R&D Ltd, Budapest, H-1097 Illatos út 7, Hungary.
Lajos SzenteCycloLab, Cyclodextrin R&D Ltd, Budapest, H-1097 Illatos út 7, Hungary.
Milo MalangaCycloLab, Cyclodextrin R&D Ltd, Budapest, H-1097 Illatos út 7, Hungary.
Salvatore SortinoLaboratory of Photochemistry, Department of Drug Sciences, University of Catania, I-95125 Viale A. Doria 6, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eosin B (EoB) and eosin Y (EoY), two xanthene dye derivatives with photosensitizing ability were prepared in high purity through an improved synthetic route. The dyes were grafted to a 6-monoamino-β-cyclodextrin scaffold under mild reaction conditions through a stable amide linkage using the coupling agent 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. The molecular conjugates, well soluble in aqueous medium, were extensively characterized by 1D and 2D NMR spectroscopy and mass spectrometry. Preliminary spectroscopic investigations showed that the β-cyclodextrin-EoY conjugate retains both the fluorescence properties and the capability to photogenerate singlet oxygen of the unbound chromophore. In contrast, the corresponding β-cyclodextrin-EoB conjugate did not show either relevant emission or photosensitizing activity probably due to aggregation in aqueous medium, which precludes any response to light excitation.

Indexed as

fluorescencephotodynamic therapyphotosensitizerssinglet oxygenxantheneβ-cyclodextrins

Identifiers

PMID28405233
PMCPMC5372748

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.