Evidence map›Paper›PMID 28405182›Full record

ArticleFrontiers in neuroscience2017

A Standardized Protocol for Stereotaxic Intrahippocampal Administration of Kainic Acid Combined with Electroencephalographic Seizure Monitoring in Mice.

Pascal Bielefeld, Amanda Sierra, Juan M Encinas, Mirjana Maletic-Savatic, Anne Anderson, Carlos P Fitzsimons

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Pascal BielefeldNeuroscience Program, Faculty of Sciences, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands.
Amanda SierraAchucarro Basque Center for NeuroscienceZamudio, Spain; Ikerbasque FoundationBilbao, Spain; University of the Basque Country (UPV/EHU)Leioa, Spain.
Juan M EncinasAchucarro Basque Center for NeuroscienceZamudio, Spain; Ikerbasque FoundationBilbao, Spain; University of the Basque Country (UPV/EHU)Leioa, Spain.
Mirjana Maletic-SavaticBaylor College of Medicine, The Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital Houston, TX, USA.
Anne AndersonBaylor College of Medicine, The Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital Houston, TX, USA.
Carlos P FitzsimonsNeuroscience Program, Faculty of Sciences, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands.
Achucarro Basque Center for Neuroscience · ESBaylor College of Medicine · USNetherlands Institute for Neuroscience · NLUniversity of Amsterdam · NL

Funding

Imaging Mass Spectrometry for metabolome mappingR01GM120033 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI LIU, ZHANDONG, MALETIC-SAVATIC, MIRJANA · 2017 to 2021
$2.5M
NIGMS NIH HHS R01 GM120033
6 · The paper itself

Abstract

Lack of scientific reproducibility is a growing concern and weak experimental practices may contribute to irreproducibility. Here, we describe an optimized and versatile protocol for stereotaxic intrahippocampal administration of Kainic Acid (KA) in mice with a C57Bl6 background. In this protocol, KA administration is combined with

Indexed as

adult hippocampal neurogenesisEEGepilepsyintrahippocampal administrationkainic acidtemporal lobe

Identifiers

PMID28405182
PMCPMC5370320
OpenAlexW2601943057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.