Evidence map›Paper›PMID 28405140›Full record

ReviewWorld journal of gastroenterology2017

Diet and microbiota in inflammatory bowel disease: The gut in disharmony.

Davy C M Rapozo, Claudio Bernardazzi, Heitor Siffert Pereira de Souza

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 4 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 4 syntheses or guidelines pooled it, 154 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Fecal transplantation for treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2018
    Pooled it
  5. Article
  6. Article
  7. Article
  8. Disrupted terminal bilirubin catabolism linksFrontiers in microbiology · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Gut microbiota dysfunction in Crohn's disease.Frontiers in cellular and infection microbiology · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Davy C M RapozoDavy C M Rapozo, Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20230-130, Brazil.
Claudio BernardazziDavy C M Rapozo, Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20230-130, Brazil.
Heitor Siffert Pereira de SouzaDavy C M Rapozo, Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20230-130, Brazil.
Instituto Nacional do Câncer · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colitis, reinforcing the hypothesis of dysbiosis as a relevant mechanism underlying inflammatory bowel disease (IBD) pathogenesis. Humans and microbes have co-existed and co-evolved for a long time in a mutually beneficial symbiotic association essential for maintaining homeostasis. However, the microbiome is dynamic, changing with age and in response to environmental modifications. Among such environmental factors, food and alimentary habits, progressively altered in modern societies, appear to be critical modulators of the microbiota, contributing to or co-participating in dysbiosis. In addition, food constituents such as micronutrients are important regulators of mucosal immunity, with direct or indirect effects on the gut microbiota. Moreover, food constituents have recently been shown to modulate epigenetic mechanisms, which can result in increased risk for the development and progression of IBD. Therefore, it is likely that a better understanding of the role of different food components in intestinal homeostasis and the resident microbiota will be essential for unravelling the complex molecular basis of the epigenetic, genetic and environment interactions underlying IBD pathogenesis as well as for offering dietary interventions with minimal side effects.

Indexed as

AnimalsAutoimmunityCrohn DiseaseDietDisease ProgressionDysbiosisEpigenesis, GeneticFoodHomeostasisHumansImmunity, MucosalInflammatory Bowel DiseasesIntestinal MucosaIntestinesMicrobiotaCrohn’s diseaseDietEpigeneticsMicrobiotaUlcerative colitis

Identifiers

PMID28405140
PMCPMC5374124
OpenAlexW2598697012

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.