ArticleScientific reports2017
Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Continuous vestibular implant stimulation partially restores eye-stabilizing reflexes.JCI insight · 2019Trial
- Optimal Human Passive Vestibulo-Ocular Reflex Adaptation Does Not Rely on Passive Training.Journal of the Association for Research in Otolaryngology : JARO · 2018Trial
- Review
- Cerebellar Purkinje cells in male macaques combine sensory and motor information to predict the sensory consequences of active self-motion.Nature communications · 2024Article
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- A prosthesis utilizing natural vestibular encoding strategies improves sensorimotor performance in monkeys.PLoS biology · 2022Article
- Article
- Long-term behavioral effects observed in mice chronically exposed to static ultra-high magnetic fields.Magnetic resonance in medicine · 2021Article
- Neural Interruption by Unilateral Labyrinthectomy Biases the Directional Preference of Otolith-Related Vestibular Neurons.Brain sciences · 2021Article
- Article
- Ionic direct current modulation evokes spike-rate adaptation in the vestibular periphery.Scientific reports · 2019Article
- Virtual Rhesus Labyrinth Model Predicts Responses to Electrical Stimulation Delivered by a Vestibular Prosthesis.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Vestibular processing during natural self-motion: implications for perception and action.Nature reviews. Neuroscience · 2019Review
- Implantable Direct Current Neural Modulation: Theory, Feasibility, and Efficacy.Frontiers in neuroscience · 2019Review
- Human Vestibulo-Ocular Reflex Adaptation Training: Time Beats Quantity.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
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Authors and funding
3 authors.
Funding
Abstract
Investigations of behaviors with well-characterized circuitry are required to understand how the brain learns new motor skills and ensures existing behaviors remain appropriately calibrated over time. Accordingly, here we recorded from neurons within different sites of the vestibulo-spinal circuitry of behaving macaque monkeys during temporally precise activation of vestibular afferents. Behaviorally relevant patterns of vestibular nerve activation generated a rapid and substantial decrease in the monosynaptic responses recorded at the first central stage of processing from neurons receiving direct input from vestibular afferents within minutes, as well as a decrease in the compensatory reflex response that lasted up to 8 hours. In contrast, afferent responses to this same stimulation remained constant, indicating that plasticity was not induced at the level of the periphery but rather at the afferent-central neuron synapse. Strikingly, the responses of neurons within indirect brainstem pathways also remained constant, even though the efficacy of their central input was significantly reduced. Taken together, our results show that rapid plasticity at the first central stage of vestibulo-spinal pathways can guide changes in motor performance, and that complementary plasticity on the same millisecond time scale within inhibitory vestibular nuclei networks contributes to ensuring a relatively robust behavioral output.
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Registered trials
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