Evidence map›Paper›PMID 28404829›Full record

ReviewJournal of neurophysiology2017

Neural mechanisms of oculomotor abnormalities in the infantile strabismus syndrome.

Mark M G Walton, Adam Pallus, Jérome Fleuriet, Michael J Mustari, Kristina Tarczy-Hornoch

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  9. Review
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  13. Review
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  15. Article
  16. Neural Plasticity Following Surgical Correction of Strabismus in Monkeys.Investigative ophthalmology & visual science · 2018
    Article
  17. Article
  18. Normal Topography and Binocularity of the Superior Colliculus in Strabismus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  19. Article
  20. Childhood Onset Strabismus: A Neurotrophic Factor Hypothesis.Journal of binocular vision and ocular motility
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mark M G WaltonWashington National Primate Research Center, University of Washington, Seattle, Washington; mark.walton@wanprc.org.
Adam PallusWashington National Primate Research Center, University of Washington, Seattle, Washington.ORCID 0000-0002-2310-4895
Jérome FleurietWashington National Primate Research Center, University of Washington, Seattle, Washington.
Michael J MustariWashington National Primate Research Center, University of Washington, Seattle, Washington.
Kristina Tarczy-HornochDepartment of Ophthalmology, University of Washington, Seattle, Washington.
University of Washington · USSeattle Children's Hospital · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
Brainstem Saccade Circuitry in StrabismusR01EY024248 · NEI · UNIVERSITY OF WASHINGTON · PI WALTON, MARK M · 2015 to 2023
$4.2M
NEI NIH HHS R01 EY024248NIH HHS P51 OD010425
6 · The paper itself

Abstract

Infantile strabismus is characterized by numerous visual and oculomotor abnormalities. Recently nonhuman primate models of infantile strabismus have been established, with characteristics that closely match those observed in human patients. This has made it possible to study the neural basis for visual and oculomotor symptoms in infantile strabismus. In this review, we consider the available evidence for neural abnormalities in structures related to oculomotor pathways ranging from visual cortex to oculomotor nuclei. These studies provide compelling evidence that a disturbance of binocular vision during a sensitive period early in life, whatever the cause, results in a cascade of abnormalities through numerous brain areas involved in visual functions and eye movements.

Indexed as

AnimalsEye MovementsHumansInfantOculomotor NerveOculomotor Nuclear ComplexStrabismusVisual CortexVisual Pathwaysneurophysiologypursuitsaccadestrabismusvision

Identifiers

PMID28404829
PMCPMC5498729
OpenAlexW2607244231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.