Evidence map›Paper›PMID 28404805›Full record

ArticleNeurology2017

Mutant IDH1 and seizures in patients with glioma.

Hao Chen, Jonathon Judkins, Cheddhi Thomas, Meijing Wu, Laith Khoury, Carolina G Benjamin, Donato Pacione, John G Golfinos, Priya Kumthekar, Farhad Ghamsari and 5 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 4 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 4 syntheses or guidelines pooled it, 254 citations in OpenAlex.

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101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Hao ChenFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Jonathon JudkinsFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Cheddhi ThomasFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Meijing WuFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Laith KhouryFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Carolina G BenjaminFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Donato PacioneFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
John G GolfinosFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Priya KumthekarFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Farhad GhamsariFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Li ChenFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Pamela LeinFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Dane M ChetkovichFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Matija SnuderlFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington.
Craig HorbinskiFrom the University of California, Davis (H.C., P.L.), CA; Departments of Neurosurgery (M.W., C.H.), Neurology (L.C., D.M.C.), Physiology (D.M.C.), and Pathology (C.H.), Feinberg School of Medicine (J.J., F.G.), Northwestern University, Chicago, IL; Departments of Pathology (C.T., M.S.) and Neurosurgery (C.G.B., D.P., J.G.G.), Langone School of Medicine, New York University, New York; and Departments of Neurosurgery (L.K.) and Cancer Biostatistics (P.K.), University of Kentucky, Lexington. craig.horbinski@northwestern.edu.
New York University · USUniversity of California, Davis · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
HCN Channel Trafficking in EpilepsyR01NS059934 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHETKOVICH, DANE M · 2008 to 2017
$3.1M
Discovery of novel small molecule antidepressantsR01MH106511 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHETKOVICH, DANE M, SCHILTZ, GARY E · 2016 to 2018
$1.1M
The Significance of Isocitrate Dehydrogenase Mutations in GliomasK08CA155764 · NCI · UNIVERSITY OF KENTUCKY · PI HORBINSKI, CRAIG MICHAEL · 2011 to 2015
$857k
NCI NIH HHS K08 CA155764NCI NIH HHS P30 CA177558NIEHS NIH HHS T32 ES007059NIMH NIH HHS R01 MH106511NINDS NIH HHS R01 NS059934
6 · The paper itself

Abstract

objectiveBecause the d-2-hydroxyglutarate (D2HG) product of mutant isocitrate dehydrogenase 1 (IDH1

methodsThree WHO grade II-IV glioma cohorts from separate institutions (total N = 712) were retrospectively assessed for the presence of preoperative seizures and tumor location, WHO grade, 1p/19q codeletion, and IDH1

resultsPreoperative seizures were observed in 18%-34% of IDH1 wild-type (IDH1

conclusionsThe D2HG product of IDH1

Indexed as

MutationAction PotentialsAnimalsBrain NeoplasmsCells, CulturedCerebral CortexChromosome DeletionChromosomes, Human, Pair 1FemaleGliomaGlutaratesHumansIsocitrate DehydrogenaseMaleMiddle AgedNeoplasm Gradingalpha-hydroxyglutarateGlutaratesIDH1 protein, humanIsocitrate Dehydrogenase

Identifiers

PMID28404805
PMCPMC5419985
OpenAlexW2605860968

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.