Evidence map›Paper›PMID 28404797›Full record

ArticleOpen biology2017

Self-adjuvanting C18 lipid vinil sulfone-PP2A vaccine: study of the induced immunomodulation against

M Gomez-Samblas, J J García-Rodríguez, M Trelis, D Bernal, F J Lopez-Jaramillo, F Santoyo-Gonzalez, S Vilchez, A M Espino, F Bolás-Fernández, A Osuna

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Mucosal Vaccination With RecombinantFrontiers in immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

M Gomez-SamblasInstituto de Biotecnología, Grupo de Bioquímica y Parasitología Molecular, Departamento de Parasitología, Universidad de Granada, Campus Universitario Fuentenueva, 18071 Granada, Spain.
J J García-RodríguezDepartamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal s/n. Ciudad Universitaria, 28040 Madrid, Spain.
M TrelisÀrea de Parasitologia, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Universitat de València, Av. V.A. Estellés, s/n, 46100 Burjassot (Valencia), Spain.
D BernalDepartament de Bioquímica i Biologia Molecular, Universitat de València, C/ Dr Moliner, 50, 46100 Burjassot (Valencia), Spain.
F J Lopez-JaramilloDepartamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, 18071 Granada, Spain.
F Santoyo-GonzalezDepartamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, 18071 Granada, Spain.
S VilchezInstituto de Biotecnología, Grupo de Bioquímica y Parasitología Molecular, Departamento de Bioquímica, Universidad de Granada, Campus Universitario Fuentenueva, 18071 Granada, Spain.
A M EspinoLaboratory of Immunology and Molecular Parasitology, Department of Microbiology, University of Puerto Rico, School of Medicine. PO Box 365067, San Juan 00936-5067, Puerto Rico.
F Bolás-FernándezDepartamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal s/n. Ciudad Universitaria, 28040 Madrid, Spain.
A OsunaInstituto de Biotecnología, Grupo de Bioquímica y Parasitología Molecular, Departamento de Parasitología, Universidad de Granada, Campus Universitario Fuentenueva, 18071 Granada, Spain aosuna@ugr.es.ORCID 0000-0002-3818-1471
Universidad de Granada · ESUniversidad Complutense de Madrid · ESUniversitat de València · ESUniversity of Puerto Rico System · PR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the importance of the adjuvant in the immunization process, very few adjuvants merge with the antigens in vaccines. A synthetic self-adjuvant oleic-vinyl sulfone (OVS) linked to the catalytic region of recombinant serine/threonine phosphatase 2A from the nematode

Indexed as

Adjuvants, ImmunologicAdministration, IntranasalAmino Acid SequenceAnimalsChemokine CCL11Chemokine CCL20FemaleGene ExpressionHelminth ProteinsInterleukinsIntestinal MucosaLipopeptidesMiceMice, Inbred AKRParasite Egg CountProtein Phosphatase 2Adjuvants, ImmunologicCcl11 protein, mouseCCL20 protein, mouseChemokine CCL11Chemokine CCL20divinyl sulfoneHelminth ProteinsInterleukinsLipopeptidesProtein Phosphatase 2Recombinant ProteinsSulfonesVaccines, Conjugatechemokinescytokineslipid vinyl sulfoneself-assembling lipopeptide rPP2ATrichuris muris vaccination

Identifiers

PMID28404797
PMCPMC5413912
OpenAlexW2607077995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.