Evidence map›Paper›PMID 28404772›Full record

ArticleProceedings. Biological sciences2017

Known mutator alleles do not markedly increase mutation rate in clinical

Daniel A Skelly, Paul M Magwene, Brianna Meeks, Helen A Murphy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings. Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel A SkellyDepartment of Biology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-2329-2216
Paul M MagweneDepartment of Biology, Duke University, Durham, NC, USA.
Brianna MeeksDepartment of Biology, The College of William and Mary, Williamsburg, VA, USA.
Helen A MurphyDepartment of Biology, The College of William and Mary, Williamsburg, VA, USA hamurphy@wm.edu.ORCID http://orcid.org/0000-0002-4363-4543

Funding

High throughput S. cerevisiae HAM, GWA & QT/QTL architectureR01GM098287 · NIGMS · DUKE UNIVERSITY · PI DIETRICH, FRED S, MAGWENE, PAUL MITAARI · 2011 to 2014
$2.1M
NIGMS NIH HHS R01 GM098287
6 · The paper itself

Abstract

Natural selection has the potential to act on all phenotypes, including genomic mutation rate. Classic evolutionary theory predicts that in asexual populations, mutator alleles, which cause high mutation rates, can fix due to linkage with beneficial mutations. This phenomenon has been demonstrated experimentally and may explain the frequency of mutators found in bacterial pathogens. By contrast, in sexual populations, recombination decouples mutator alleles from beneficial mutations, preventing mutator fixation. In the facultatively sexual yeast

Indexed as

Evolution, MolecularMutation RateAllelesMutationPhylogenySaccharomyces cerevisiaeSelection, Geneticgenetic backgroundmutation ratemutatorsSaccharomyces cerevisiae

Identifiers

PMID28404772
PMCPMC5394658

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.