Evidence map›Paper›PMID 28404751›Full record

ArticleMolecular biology of the cell2017

Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin.

Mariah L Hanley, Tae Yeon Yoo, Matthew Sonnett, Daniel J Needleman, Timothy J Mitchison

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mariah L HanleyDepartment of Systems Biology, Harvard Medical School, Boston, MA 02114-5701.
Tae Yeon YooJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138-2902.
Matthew SonnettDepartment of Systems Biology, Harvard Medical School, Boston, MA 02114-5701.
Daniel J NeedlemanJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138-2902.
Timothy J MitchisonDepartment of Systems Biology, Harvard Medical School, Boston, MA 02114-5701 timothy_mitchison@hms.harvard.edu.
Harvard University · US

Funding

MICROTUBULE DYNAMICS AND MITOTIC MECHANISMR01GM039565 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MITCHISON, TIMOTHY J · 1988 to 2018
$6.2M
MICROTUBULE DYNAMICS AND MITOTIC MECHANISMR37GM039565 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MITCHISON, TIMOTHY J · 1997 to 2006
$3.2M
Using Quantitative Proteomics to Understand Mitotic Spindle Composition and FunctionF31GM116451 · NIGMS · HARVARD MEDICAL SCHOOL · PI SONNETT, MATTHEW MCLEAN · 2015 to 2017
$131k
NIGMS NIH HHS F31 GM116451NIGMS NIH HHS R01 GM039565NIGMS NIH HHS R37 GM039565
6 · The paper itself

Abstract

The chromosomal passenger complex (CPC) is a conserved, essential regulator of cell division. As such, significant anti-cancer drug development efforts have been focused on targeting it, most notably by inhibiting its AURKB kinase subunit. The CPC is activated by AURKB-catalyzed autophosphorylation on multiple subunits, but how this regulates CPC interactions with other mitotic proteins remains unclear. We investigated the hydrodynamic behavior of the CPC in

Indexed as

AnimalsCell DivisionChromatinChromosomal Proteins, Non-HistoneChromosomesHeLa CellsHumansHydrodynamicsMicrotubulesMitosisMolecular ChaperonesNuclear ProteinsNucleophosminNucleoplasminsSpindle ApparatusXenopus laevisChromatinChromosomal Proteins, Non-HistoneMolecular ChaperonesNPM1 protein, humanNuclear ProteinsNucleophosminNucleoplasminsXenopus Proteins

Identifiers

PMID28404751
PMCPMC5449145
OpenAlexW2607226540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.