Evidence map›Paper›PMID 28404685›Full record

ArticleEndocrine connections2017

Rising maternal circulating GH during murine pregnancy suggests placental regulation.

Kathryn L Gatford, Beverly S Muhlhausler, Lili Huang, Pamela Su-Lin Sim, Claire T Roberts, Johannes D Velhuis, Chen Chen

Open access · goldAbstract read
In one paragraph

Article in Endocrine connections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. A head start: The relationship of placental factors to craniofacial and brain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Review
  7. Article
  8. Impact of sex and pregnancy on hepatic CYP3A4 expression and activity in a humanized mouse model.Drug metabolism and disposition: the biological fate of chemicals · 2025
    Article
  9. Article
  10. Insulin signaling in development.Development (Cambridge, England) · 2023
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Central growth hormone action regulates metabolism during pregnancy.American journal of physiology. Endocrinology and metabolism · 2019
    Article
  18. Effects of growth hormone in the central nervous system.Archives of endocrinology and metabolism
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kathryn L GatfordRobinson Research InstituteThe University of Adelaide, Adelaide, Australia kathy.gatford@adelaide.edu.au.
Beverly S MuhlhauslerFOOD plus Research CentreSchool of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia.
Lili HuangSchool of Biomedical SciencesUniversity of Queensland, St Lucia, Brisbane, Australia.
Pamela Su-Lin SimFOOD plus Research CentreSchool of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia.
Claire T RobertsRobinson Research InstituteThe University of Adelaide, Adelaide, Australia.
Johannes D VelhuisEndocrine Research UnitMayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, USA.
Chen ChenSchool of Biomedical SciencesUniversity of Queensland, St Lucia, Brisbane, Australia.
University of Adelaide · AUUniversity of Queensland · AUMayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Placenta-derived hormones including growth hormone (GH) in humans contribute to maternal adaptation to pregnancy, and intermittent maternal GH administration increases foetal growth in several species. Both patterns and abundance of circulating GH are important for its activity, but their changes during pregnancy have only been reported in humans and rats. The aim of the present study was to characterise circulating profiles and secretory characteristics of GH in non-pregnant female mice and throughout murine pregnancy. Circulating GH concentrations were measured in whole blood (2 μL) collected every 10 min for 6 h in non-pregnant diestrus female C57Bl/6J mice (

Indexed as

growth hormonemouseplacentapregnancyprofile

Identifiers

PMID28404685
PMCPMC5457489
OpenAlexW2607004909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.