Evidence map›Paper›PMID 28404679›Full record

ArticleJournal of clinical microbiology2017

Evaluation of a TaqMan Array Card for Detection of Central Nervous System Infections.

Clayton O Onyango, Vladimir Loparev, Shirley Lidechi, Vinod Bhullar, D Scott Schmid, Kay Radford, Michael K Lo, Paul Rota, Barbara W Johnson, Jorge Munoz and 6 more

Open access · bronzeAbstract readValidation Study
In one paragraph

Article in Journal of clinical microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. A need to raise the bar - A systematic review of temporal trends in diagnostics for Japanese encephalitis virus infection, and perspectives for future research.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Pooled it
  2. Article
  3. Measles Without Rash During Acute Febrile Illness Surveillance in Tanzania, 2023-2024.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Hybrid capture shotgun sequencing detected unexpected viruses in the cerebrospinal fluid of children with acute meningitis and encephalitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
  16. Development and Implementation of Multiplex TaqMan Array Cards for Specimen Testing at Child Health and Mortality Prevention Surveillance Site Laboratories.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Clayton O OnyangoDivision of Global Health Protection, Centers for Disease Control and Prevention, Nairobi, Kenya xwl4@cdc.gov.
Vladimir LoparevNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Shirley LidechiKenya Medical Research Institute, Nairobi, Kenya.
Vinod BhullarNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
D Scott SchmidNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Kay RadfordNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Michael K LoNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Paul RotaNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Barbara W JohnsonNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jorge MunozNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Martina OnekoKenya Medical Research Institute, Nairobi, Kenya.
Deron BurtonNational Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Carolyn M BlackNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
John NeatherlinDivision of Global Health Protection, Centers for Disease Control and Prevention, Nairobi, Kenya.
Joel M MontgomeryDivision of Global Health Protection, Centers for Disease Control and Prevention, Nairobi, Kenya.
Barry FieldsDivision of Global Health Protection, Centers for Disease Control and Prevention, Nairobi, Kenya.
Centers for Disease Control and Prevention · USCenter for Global Health · USKenya Medical Research Institute · KENational Center for Emerging and Zoonotic Infectious Diseases · USNational Center for Immunization and Respiratory Diseases · USCenters for Disease Control and Prevention · KENational Center for HIV/AIDS Viral Hepatitis STD and TB Prevention · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections of the central nervous system (CNS) are often acute, with significant morbidity and mortality. Routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-Saharan Africa. We developed a TaqMan array card (TAC) that detects multiple pathogens simultaneously from cerebrospinal fluid. The 21-pathogen CNS multiple-pathogen TAC (CNS-TAC) assay includes two parasites (

Indexed as

AdolescentAdultAfrica South of the SaharaAgedAged, 80 and overAmoebozoaBacteriaCentral Nervous System InfectionsChildChild, PreschoolFemaleHumansInfantMaleMicrobiological TechniquesMiddle Agedcentral nervous systemencephalitismeningitisTaqMan PCR

Identifiers

PMID28404679
PMCPMC5483905
OpenAlexW2680254013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.