ArticleJournal of lipid research2017
Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids.
Erratum issuedOpen access · hybridAbstract read
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Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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35citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Energy Expenditure Improved Risk Factors Associated with Renal Function Loss in NAFLD and MetS Patients.Nutrients · 2021Trial
- Paracetamol (acetaminophen) intoxication and basal fatty tubular vacuolisation: a case-control study and review of the literature.International journal of legal medicine · 2026Review
- Kidney-Vascular Metabolic Crosstalk: Altered Lipoproteins in CKD.Circulation research · 2026Review
- Colorectal cancer-derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver.Molecular oncology · 2026Article
- Dehydration promotes intracellular lipid synthesis and accumulation.Nature communications · 2026Article
- Chronic exposure to low levels of glyphosate and metals induces kidney dysfunction.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Emerging roles of PCSK9 in kidney disease: lipid metabolism, megalin regulation and proteinuria.Pflugers Archiv : European journal of physiology · 2025Review
- Kidney lipid metabolism: impact on pediatric kidney diseases and modulation by early-life nutrition.Pediatric nephrology (Berlin, Germany) · 2025Review
- Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease.bioRxiv : the preprint server for biology · 2025Article
- Quantifying renal lipid accumulation in obese murine models using Magnetic Resonance Imaging (MRI).Biochemical and biophysical research communications · 2025Article
- Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease.Science advances · 2024Article
- The key role of altered tubule cell lipid metabolism in kidney disease development.Kidney international · 2024Review
- Targeting de novo lipogenesis to mitigate kidney disease.The Journal of clinical investigation · 2024Article
- Lipotoxicity and immunometabolism in ischemic acute kidney injury: current perspectives and future directions.Frontiers in pharmacology · 2024Review
- Direct androgen receptor control of sexually dimorphic gene expression in the mammalian kidney.Developmental cell · 2023Article
- Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.Nature communications · 2023Article
- Sex differences in obesity-induced renal lipid accumulation revealed by lipidomics: a role of adiponectin/AMPK axis.Biology of sex differences · 2023Article
- Direct androgen receptor regulation of sexually dimorphic gene expression in the mammalian kidney.bioRxiv : the preprint server for biology · 2023Article
- Visualizing increased uptake of [18F]FDG and [18F]FTHA in kidneys from obese high-fat diet fed C57BL/6J mice using PET/CT ex vivo.PloS one · 2023Article
- Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis.Cell metabolism · 2022Article
Corrections and comments
- Erratum issuedERRATUM.2017
Authors and funding
16 authors at 7 institutions in 2 countries.
Diego ScerboDivision of Endocrinology, Diabetes, and Metabolism, New York University School of Medicine, New York, NY.
Ni-Huiping SonDivision of Endocrinology, Diabetes, and Metabolism, New York University School of Medicine, New York, NY.
Alaa SirwiDepartment of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY.
Lixia ZengDivision of Nephrology, University of Michigan, Ann Arbor, MI.
Kelli M SasDivision of Nephrology, University of Michigan, Ann Arbor, MI.
Vincenza CifarelliDepartment of Medicine, Washington University, St. Louis, MO.
Gabriele SchoiswohlDivision of Endocrinology, University of Pittsburgh, Pittsburgh, PA.
Lesley-Ann HugginsDivision of Endocrinology, Diabetes, and Metabolism, New York University School of Medicine, New York, NY.
Namrata GumasteDivision of Endocrinology, Diabetes, and Metabolism, New York University School of Medicine, New York, NY.
Yunying HuDivision of Endocrinology, Diabetes, and Metabolism, New York University School of Medicine, New York, NY.
Subramaniam PennathurDivision of Nephrology, University of Michigan, Ann Arbor, MI.
Nada A AbumradDepartment of Medicine, Washington University, St. Louis, MO.
Erin E KershawDivision of Endocrinology, University of Pittsburgh, Pittsburgh, PA.
M Mahmood HussainDepartment of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY.
Katalin SusztakDivision of Renal Electrolyte and Hypertension, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Ira J GoldbergDivision of Endocrinology, Diabetes, and Metabolism, New York University School of Medicine, New York, NY ira.goldberg@nyumc.org.
New York University · USUniversity of Michigan–Ann Arbor · USUniversity of Pittsburgh · USWashington University in St. Louis · USState University of New York · USSUNY Downstate Health Sciences University · USUniversity of Pennsylvania · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MMichigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3MIntegrated Systems Biology Approach to Diabetic Microvascular ComplicationsR24DK082841 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABCOUWER, STEVEN F, BROSIUS, FRANK C · 2008 to 2020
$13.1MUniversity of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PENNATHUR, SUBRAMANIAM · 2008 to 2022
$12.9MStatistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1MRole of the Notch Pathway in Kidney InjuryR01DK076077 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KATALIN SUSZTAK · 2007 to 2026
$8.0MCD36 AND INTESTINAL FAT ABSORPTIONR01DK060022 · NIDDK · WASHINGTON UNIVERSITY · PI ABUMRAD, NADA A. · 2001 to 2021
$7.7MEpigenetics of Chronic Kidney DiseaseR01DK087635 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KATALIN SUSZTAK · 2009 to 2026
$7.0MPathways of Tissue Lipid UptakeR01HL045095 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABUMRAD, NADA A., GOLDBERG, IRA J · 1991 to 2024
$6.9MMechanisms of Fatty Acid Uptake By Cardiac MuscleR01HL073029 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GOLDBERG, IRA J · 2003 to 2021
$6.8MNCATS NIH HHS UL1 TR000433NCI NIH HHS P30 CA016087NHLBI NIH HHS R01 HL045095NHLBI NIH HHS R01 HL073029NHLBI NIH HHS R37 HL045095NIDDK NIH HHS DP3 DK094292NIDDK NIH HHS DP3 DK108220NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK081943NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK033301NIDDK NIH HHS R01 DK060022NIDDK NIH HHS R01 DK076077NIDDK NIH HHS R01 DK087635NIDDK NIH HHS R01 DK090166NIDDK NIH HHS R01 DK105821NIDDK NIH HHS R24 DK082841NIDDK NIH HHS R56 DK046900NIDDK NIH HHS R56 DK090166NIDDK NIH HHS U24 DK097153
Abstract
Lipid accumulation is a pathological feature of every type of kidney injury. Despite this striking histological feature, physiological accumulation of lipids in the kidney is poorly understood. We studied whether the accumulation of lipids in the fasted kidney are derived from lipoproteins or NEFAs. With overnight fasting, kidneys accumulated triglyceride, but had reduced levels of ceramide and glycosphingolipid species. Fasting led to a nearly 5-fold increase in kidney uptake of plasma [
Indexed as
AnimalsFastingFatty Acids, NonesterifiedFemaleKidneyMaleMiceMice, Inbred C57BLOxidation-ReductionTriglyceridesFatty Acids, NonesterifiedTriglyceridescluster of differentiation 36kidney metabolismlipoprotein lipase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.