ArticleGenes & development2017
BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.
Erratum issuedOpen access · diamondAbstract read
In one paragraph
Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Sensory neuron BRAF mediates opioid-induced hyperalgesia and tolerance via presynaptic NMDA receptor hyperactivity.The Journal of clinical investigation · 2026Article
- Article
- Forebrain-Specific B-raf Deficiency Reduces NMDA Current and Enhances Small-Conductance CaInternational journal of molecular sciences · 2025Article
- Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models.The Journal of clinical investigation · 2025Article
- Architectural organization of ∼1,500-neuron modular minicolumnar disinhibitory circuits in healthy and Alzheimer's cortices.Cell reports · 2023Article
- OncogenicNeural regeneration research · 2023Article
- Co-dependent regulation of p-BRAF and potassium channel KCNMA1 levels drives glioma progression.Cellular and molecular life sciences : CMLS · 2023Article
- Organizational principles of amygdalar input-output neuronal circuits.Molecular psychiatry · 2021Article
- The Property-Based Practical Applications and Solutions of Genetically Encoded Acetylcholine and Monoamine Sensors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Genetically encoded sensors enable micro- and nano-scopic decoding of transmission in healthy and diseased brains.Molecular psychiatry · 2021Review
- BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons.Journal of neurophysiology · 2020Article
- RAS GTPase-dependent pathways in developmental diseases: old guys, new lads, and current challenges.Current opinion in cell biology · 2018Review
- CRISPR-Cas9 human gene replacement and phenomic characterization inDisease models & mechanisms · 2018Article
- A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies.Nature biotechnology · 2018Article
- Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains.Neuron · 2018Article
- Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 8 institutions in 3 countries.
Chae-Seok LimDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Xi KangDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Vincent MirabellaDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
Huaye ZhangDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
Qian BuWaisman Center, University of Wisconsin School of Medicine, Madison, Wisconsin 53705, USA.
Yoichi ArakiDepartment of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Elizabeth T HoangDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Shiqiang WangState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Ying ShenDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health, Zhejiang University School of Medicine, Hangzhou 310058, China.
Sukwoo ChoiDepartment of Biological Sciences, Seoul National University, Seoul 08826, Korea.
Bong-Kiun KaangDepartment of Biological Sciences, Seoul National University, Seoul 08826, Korea.
Qiang ChangWaisman Center, University of Wisconsin School of Medicine, Madison, Wisconsin 53705, USA.
Zhiping P PangDepartment of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
Richard L HuganirDepartment of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
J Julius ZhuDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Seoul National University · KRUniversity of Virginia · USJohns Hopkins University · USRutgers, The State University of New Jersey · USUniversity of Wisconsin–Madison · USPeking University · CNVirginia College · USZhejiang University · CN
Funding
PDZ DOMAINS AND EXCITATORY SYNAPTIC FUNCTIONR01NS036715 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1997 to 2020
$8.6MDeciphering the neural basis of alcohol use disorders using human and mouse neuronsR01AA023797 · NIAAA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ZHIPING P. PANG · 2016 to 2026
$4.8MRegulation of the NMDA Receptor Signaling ComplexR01MH064856 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 2002 to 2011
$3.6MThe Dynamic AMPA Receptor Interactome During Plasticity and LearningR37NS036715 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Richard L Huganir · 2022 to 2026
$3.2MIn Vivo Function of Neuronal Activity-Induced MeCP2 phosphorylationR01HD064743 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI CHANG, QIANG · 2010 to 2021
$3.0MSynapse-specific Regulation of Transmission and Integration in the Barrel CortexR01NS053570 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2006 to 2013
$2.2MPolarity determinants in synaptic stability and plasticityR01NS089578 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI ZHANG, HUAYE · 2015 to 2019
$1.9MCalcium channel and glutamate receptor signaling at synapsesR01NS091452 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2015 to 2019
$1.7MSynaptic Depression: Focus on Cdk5 SignalingR01NS092548 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2015 to 2019
$1.7MThe PAR-6/aPKC Polarity Complex in Synaptic Assembly and FunctionR00NS065183 · NINDS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI ZHANG, HUAYE · 2011 to 2013
$738kInterneuron-based cell therapy for Fragile XR21NS094980 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2016 to 2017
$431kThe PAR-6/aPKC Polarity Complex in Synaptic Assembly and FunctionK99NS065183 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHANG, HUAYE · 2009 to 2010
$180kHoward Hughes Medical InstituteNIAAA NIH HHS R01 AA023797NICHD NIH HHS R01 HD064743NIMH NIH HHS F30 MH108321NIMH NIH HHS R01 MH064856NINDS NIH HHS K99 NS065183NINDS NIH HHS R00 NS065183NINDS NIH HHS R01 NS036715NINDS NIH HHS R01 NS053570NINDS NIH HHS R01 NS089578NINDS NIH HHS R01 NS091452NINDS NIH HHS R01 NS092548NINDS NIH HHS R21 NS094980NINDS NIH HHS R37 NS036715
Abstract
Rapid advances in genetics are linking mutations on genes to diseases at an exponential rate, yet characterizing the gene-mutation-cell-behavior relationships essential for precision medicine remains a daunting task. More than 350 mutations on small GTPase
Indexed as
MutationAnimalsCells, CulturedDiseaseFemaleGene Transfer TechniquesHumansLentivirusMaleMAP Kinase Signaling SystemMice, Inbred C57BLNeuronsProto-Oncogene Proteins B-rafRats, Sprague-DawleySynaptic TransmissionTissue Culture TechniquesBRAF protein, humanProto-Oncogene Proteins B-rafBRafcancerCFC syndromeneurodevelopmental disordersynaptic transmission
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.