Evidence map›Paper›PMID 28404627›Full record

ArticleCirculation. Heart failure2017

Multiphasic Regulation of Systemic and Peripheral Organ Metabolic Responses to Cardiac Hypertrophy.

Chong Wee Liew, Shanshan Xu, Xuerong Wang, Maximilian McCann, Hyerim Whang Kong, Andrew C Carley, Jingbo Pang, Giamila Fantuzzi, J Michael O'Donnell, E Douglas Lewandowski

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. UCP1-dependent brown adipose activation accelerates cardiac metabolic remodeling and reduces initial hypertrophic and fibrotic responses to pathological stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  5. Metabolic flux in the driver's seat during cardiac health and disease.Journal of molecular and cellular cardiology · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chong Wee LiewFrom the Department of Physiology and Biophysics (C.W.L., S.X., M.M., H.W.K., A.C.C., J.M.O., E.D.L.) and Center for Cardiovascular Research (X.W., A.C.C., J.M.O., E.D.L.), University of Illinois College of Medicine at Chicago; Department of Kinesiology and Nutrition, University of Illinois at Chicago College of Applied Health Sciences (J.P., G.F.); and Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (A.C.C., E.D.L.).
Shanshan XuFrom the Department of Physiology and Biophysics (C.W.L., S.X., M.M., H.W.K., A.C.C., J.M.O., E.D.L.) and Center for Cardiovascular Research (X.W., A.C.C., J.M.O., E.D.L.), University of Illinois College of Medicine at Chicago; Department of Kinesiology and Nutrition, University of Illinois at Chicago College of Applied Health Sciences (J.P., G.F.); and Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (A.C.C., E.D.L.).
Xuerong WangFrom the Department of Physiology and Biophysics (C.W.L., S.X., M.M., H.W.K., A.C.C., J.M.O., E.D.L.) and Center for Cardiovascular Research (X.W., A.C.C., J.M.O., E.D.L.), University of Illinois College of Medicine at Chicago; Department of Kinesiology and Nutrition, University of Illinois at Chicago College of Applied Health Sciences (J.P., G.F.); and Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (A.C.C., E.D.L.).
Maximilian McCannFrom the Department of Physiology and Biophysics (C.W.L., S.X., M.M., H.W.K., A.C.C., J.M.O., E.D.L.) and Center for Cardiovascular Research (X.W., A.C.C., J.M.O., E.D.L.), University of Illinois College of Medicine at Chicago; Department of Kinesiology and Nutrition, University of Illinois at Chicago College of Applied Health Sciences (J.P., G.F.); and Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (A.C.C., E.D.L.).
Hyerim Whang KongFrom the Department of Physiology and Biophysics (C.W.L., S.X., M.M., H.W.K., A.C.C., J.M.O., E.D.L.) and Center for Cardiovascular Research (X.W., A.C.C., J.M.O., E.D.L.), University of Illinois College of Medicine at Chicago; Department of Kinesiology and Nutrition, University of Illinois at Chicago College of Applied Health Sciences (J.P., G.F.); and Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (A.C.C., E.D.L.).
Andrew C CarleyFrom the Department of Physiology and Biophysics (C.W.L., S.X., M.M., H.W.K., A.C.C., J.M.O., E.D.L.) and Center for Cardiovascular Research (X.W., A.C.C., J.M.O., E.D.L.), University of Illinois College of Medicine at Chicago; Department of Kinesiology and Nutrition, University of Illinois at Chicago College of Applied Health Sciences (J.P., G.F.); and Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (A.C.C., E.D.L.).
Jingbo PangFrom the Department of Physiology and Biophysics (C.W.L., S.X., M.M., H.W.K., A.C.C., J.M.O., E.D.L.) and Center for Cardiovascular Research (X.W., A.C.C., J.M.O., E.D.L.), University of Illinois College of Medicine at Chicago; Department of Kinesiology and Nutrition, University of Illinois at Chicago College of Applied Health Sciences (J.P., G.F.); and Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (A.C.C., E.D.L.).
Giamila FantuzziFrom the Department of Physiology and Biophysics (C.W.L., S.X., M.M., H.W.K., A.C.C., J.M.O., E.D.L.) and Center for Cardiovascular Research (X.W., A.C.C., J.M.O., E.D.L.), University of Illinois College of Medicine at Chicago; Department of Kinesiology and Nutrition, University of Illinois at Chicago College of Applied Health Sciences (J.P., G.F.); and Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (A.C.C., E.D.L.).
J Michael O'DonnellFrom the Department of Physiology and Biophysics (C.W.L., S.X., M.M., H.W.K., A.C.C., J.M.O., E.D.L.) and Center for Cardiovascular Research (X.W., A.C.C., J.M.O., E.D.L.), University of Illinois College of Medicine at Chicago; Department of Kinesiology and Nutrition, University of Illinois at Chicago College of Applied Health Sciences (J.P., G.F.); and Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (A.C.C., E.D.L.).
E Douglas LewandowskiFrom the Department of Physiology and Biophysics (C.W.L., S.X., M.M., H.W.K., A.C.C., J.M.O., E.D.L.) and Center for Cardiovascular Research (X.W., A.C.C., J.M.O., E.D.L.), University of Illinois College of Medicine at Chicago; Department of Kinesiology and Nutrition, University of Illinois at Chicago College of Applied Health Sciences (J.P., G.F.); and Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (A.C.C., E.D.L.). dougl@sbpdiscovery.org.
University of Illinois Chicago · US

Funding

Magnetic Resonance of Cardiac C13 Flux & Metabolism RateR01HL049244 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEWANDOWSKI, E DOUGLAS · 1993 to 2018
$3.7M
Maladaptive Expression of Metabolic Enzymes and Activity in Heart FailureR01HL132525 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI LEWANDOWSKI, E DOUGLAS · 2016 to 2019
$2.5M
Gender Effects on Remodeling of Lipid and Sarcomere Dynamics in HypertrophyR01HL113057 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEWANDOWSKI, E DOUGLAS · 2013 to 2016
$2.2M
EMC10, a novel obesity-regulated circulating factor, regulates energy and metabolic homeostasisR01DK109015 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIEW, CHONG WEE · 2016 to 2020
$1.8M
Role of the transcriptional coregulator, TRIP Br2, in adipocyte metabolismR00DK090210 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIEW, CHONG WEE · 2012 to 2014
$724k
NHLBI NIH HHS R01 HL049244NHLBI NIH HHS R01 HL113057NHLBI NIH HHS R01 HL132525NIDDK NIH HHS R00 DK090210NIDDK NIH HHS R01 DK109015
6 · The paper itself

Abstract

backgroundReduced fat oxidation in hypertrophied hearts coincides with a shift of carnitine palmitoyl transferase I from muscle to increased liver isoforms. Acutely increased carnitine palmitoyl transferase I in normal rodent hearts has been shown to recapitulate the reduced fat oxidation and elevated atrial natriuretic peptide message of cardiac hypertrophy. METHODS AND

resultsBecause of the potential for reduced fat oxidation to affect cardiac atrial natriuretic peptide, and thus, induce adipose lipolysis, we studied peripheral and systemic metabolism in male C57BL/6 mice model of transverse aortic constriction in which left ventricular hypertrophy occurred by 2 weeks without functional decline until 16 weeks (ejection fraction, -45.6%; fractional shortening, -22.6%). We report the first evidence for initially improved glucose tolerance and insulin sensitivity in response to 2 weeks transverse aortic constriction versus sham, linked to enhanced insulin signaling in liver and visceral adipose tissue (epididymal white adipose tissue [WAT]), reduced WAT inflammation, elevated adiponectin, mulitilocular subcutaneous adipose tissue (inguinal WAT) with upregulated oxidative/thermogenic gene expression, and downregulated lipolysis and lipogenesis genes in epididymal WAT. By 6 weeks transverse aortic constriction, the metabolic profile reversed with impaired insulin sensitivity and glucose tolerance, reduced insulin signaling in liver, epididymal WAT and heart, and downregulation of oxidative enzymes in brown adipose tissue and oxidative and lipogenic genes in inguinal WAT.

conclusionsChanges in insulin signaling, circulating natriuretic peptides and adipokines, and varied expression of adipose genes associated with altered insulin response/glucose handling and thermogenesis occurred prior to any functional decline in transverse aortic constriction hearts. The findings demonstrate multiphasic responses in extracardiac metabolism to pathogenic cardiac stress, with early iWAT browning providing potential metabolic benefits.

Indexed as

Adipose Tissue, BrownAdipose Tissue, WhiteAnimalsCardiomegalyEnergy MetabolismInsulin ResistanceLipid MetabolismMaleMice, Inbred C57BLObesityOxidation-ReductionSignal Transductionadipose tissuehypertrophyinsulin resistancemetabolismpressure overload

Identifiers

PMID28404627
PMCPMC5466817
OpenAlexW2605417082

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.