Evidence map›Paper›PMID 28404605›Full record

ArticleGenetics2017

Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects in

Sandra G Zimmerman, Gennifer E Merrihew, Michael J MacCoss, Celeste A Berg

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. A framework for quality control in quantitative proteomics.bioRxiv : the preprint server for biology · 2024
    Article
  4. Finishing the egg.Genetics · 2024
    Article
  5. Article
  6. Evolution of theInsects · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sandra G ZimmermanDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195-5065.ORCID 0000-0002-2274-5471
Gennifer E MerrihewDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195-5065.ORCID 0000-0003-4903-0318
Michael J MacCossDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195-5065.ORCID 0000-0003-1853-0256
Celeste A BergDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195-5065 caberg@uw.edu.
University of Washington · US

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI YATES III, JOHN R · 2012 to 2021
$20.7M
Regulation of tubulogenesis in the Drosophila ovaryR01GM079433 · NIGMS · UNIVERSITY OF WASHINGTON · PI BERG, CELESTE A. · 2009 to 2023
$4.2M
Leica SP8 WWL Confocal MicroscopeS10OD016240 · OD · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 2014 to 2014
$581k
NHGRI NIH HHS T32 HG000035NIGMS NIH HHS P41 GM103533NIGMS NIH HHS R01 GM079433NIH HHS S10 OD016240
6 · The paper itself

Abstract

Elevated levels of human chitinase-like proteins (CLPs) are associated with numerous chronic inflammatory diseases and several cancers, often correlating with poor prognosis. Nevertheless, there is scant knowledge of their function. The CLPs normally mediate immune responses and wound healing and, when upregulated, they can promote disease progression by remodeling tissue, activating signaling cascades, stimulating proliferation and migration, and by regulating adhesion. We identified Imaginal disc growth factors (Idgfs), orthologs of human CLPs CHI3L1, CHI3L2, and OVGP1, in a proteomics analysis designed to discover factors that regulate tube morphogenesis in a

Indexed as

ProteomicsAnimalsChitinase-3-Like Protein 1ChitinasesDrosophila melanogasterDrosophila ProteinsGlycoproteinsHumansImaginal DiscsIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsMorphogenesisOogenesisTranscription FactorsBWK protein, DrosophilaCHI3L2 protein, humanChitinase-3-Like Protein 1ChitinasesDrosophila ProteinsGlycoproteinsIdgf2 protein, DrosophilaIdgf4 protein, DrosophilaIdgf6 protein, Drosophilaimaginal disc growth factor 1, DrosophilaIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsOVGP1 protein, humanTranscription Factorschitinase-like proteinsdorsal appendageimaginal disc growth factorsmorphogenesisproteomics

Identifiers

PMID28404605
PMCPMC5499198
OpenAlexW2606420355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.