Evidence map›Paper›PMID 28404583›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017

Acute hypoxia activates neuroendocrine, but not presympathetic, neurons in the paraventricular nucleus of the hypothalamus: differential role of nitric oxide.

K Max Coldren, De-Pei Li, David D Kline, Eileen M Hasser, Cheryl M Heesch

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 43 citations in OpenAlex.

  1. Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
  11. AMPK and the Need to Breathe and Feed: What's the Matter with Oxygen?International journal of molecular sciences · 2020
    Review
  12. Article
  13. Article
  14. The PVN enhances cardiorespiratory responses to acute hypoxia via input to the nTS.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
  15. Article
  16. Article
  17. Hydrogen peroxide inhibits neurons in the paraventricular nucleus of the hypothalamus via potassium channel activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
  18. Article
  19. Review
  20. Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii.American journal of physiology. Regulatory, integrative and comparative physiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

K Max ColdrenDepartment of Biomedical Sciences, University of Missouri, Columbia, Missouri.
De-Pei LiDepartment of Critical Care, University of Texas MD Anderson Cancer Center, Houston, Texas.
David D KlineDepartment of Biomedical Sciences, University of Missouri, Columbia, Missouri.ORCID 0000-0003-3269-0184
Eileen M HasserDepartment of Biomedical Sciences, University of Missouri, Columbia, Missouri.
Cheryl M HeeschDepartment of Biomedical Sciences, University of Missouri, Columbia, Missouri; HeeschC@missouri.edu.
University of Missouri · USThe University of Texas MD Anderson Cancer Center · US

Funding

Plasticity of nTS Output Neurons In Acute and Chronic HypoxiaR01HL098602 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CUMMINGS, KEVIN JAMES, HASSER, EILEEN M · 2010 to 2023
$8.5M
Hypothalamic Neuronal Plasticity in Chronic StressR01MH096086 · NIMH · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, DE-PEI · 2013 to 2017
$1.8M
NHLBI NIH HHS R01 HL098602NIMH NIH HHS R01 MH096086
6 · The paper itself

Abstract

Hypoxia results in decreased arterial Po

Indexed as

Acute DiseaseAdrenergic FibersAnimalsArginine VasopressinCorticotropin-Releasing HormoneDisease Models, AnimalEpendymoglial CellsHypoxiaMaleNeural InhibitionNeuroendocrine CellsNitrergic NeuronsNitric OxideNitric Oxide Synthase Type IParaventricular Hypothalamic NucleusPhenotypeArginine VasopressinCorticotropin-Releasing HormoneNitric OxideNitric Oxide Synthase Type INos1 protein, ratVimentinAVPcorticotropin-releasing hormoneCRHmedian eminencenitric oxidevasopressin

Identifiers

PMID28404583
PMCPMC6148210
OpenAlexW2606666045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.