Evidence map›Paper›PMID 28404506›Full record

ArticleExperimental gerontology2017

Associations of 24-hour sleep duration and CT-derived measurements of muscle and bone: The AGES-Reykjavik Study.

Elisa A Marques, Pedro Figueiredo, Vilmundur Gudnason, Thomas Lang, Gunnar Sigurdsson, Sigurdur Sigurdsson, Thor Aspelund, Kristin Siggeirsdottir, Lenore Launer, Gudny Eiriksdottir and 1 more

Abstract read
In one paragraph

Article in Experimental gerontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Sleep disruptions and bone health: what do we know so far?Current opinion in endocrinology, diabetes, and obesity · 2021
    Review
  6. Article
  7. Article
  8. Sleep duration and bone health measures in older men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Article
  9. The importance of the circadian system & sleep for bone health.Metabolism: clinical and experimental · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elisa A MarquesLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, 7201 Wisconsin Avenue, Gateway Building, Suite 2N300, Bethesda, MD 20892-9205, USA. Electronic address: elisa.marques@nih.gov.
Pedro FigueiredoLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, 7201 Wisconsin Avenue, Gateway Building, Suite 2N300, Bethesda, MD 20892-9205, USA; Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia, ISMAI, Av. Carlos Oliveira Campos, Castelo da Maia 4475-690, Maia, Portugal.
Vilmundur GudnasonIcelandic Heart Association Research Institute, Kópavogur, Holtasmari 1, IS-201 Kópavogur, Iceland; University of Iceland, Reykjavik, Sæmundargata 2, 101 Reykjavík Ssn: 600169-2039, Iceland.
Thomas LangDepartment of Radiology and Biomedical Imaging, University of California, 505 Parnassus Ave, San Francisco, CA 94143, USA.
Gunnar SigurdssonIcelandic Heart Association Research Institute, Kópavogur, Holtasmari 1, IS-201 Kópavogur, Iceland; University of Iceland, Reykjavik, Sæmundargata 2, 101 Reykjavík Ssn: 600169-2039, Iceland; Landspitali-University Hospital, 101 Reykjavik, Iceland.
Sigurdur SigurdssonIcelandic Heart Association Research Institute, Kópavogur, Holtasmari 1, IS-201 Kópavogur, Iceland.
Thor AspelundIcelandic Heart Association Research Institute, Kópavogur, Holtasmari 1, IS-201 Kópavogur, Iceland; Centre of Public Health Sciences, University of Iceland, Stapi v. Hringbraut, 107 Reykjavík, Iceland.
Kristin SiggeirsdottirIcelandic Heart Association Research Institute, Kópavogur, Holtasmari 1, IS-201 Kópavogur, Iceland.
Lenore LaunerLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, 7201 Wisconsin Avenue, Gateway Building, Suite 2N300, Bethesda, MD 20892-9205, USA.
Gudny EiriksdottirIcelandic Heart Association Research Institute, Kópavogur, Holtasmari 1, IS-201 Kópavogur, Iceland.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, 7201 Wisconsin Avenue, Gateway Building, Suite 2N300, Bethesda, MD 20892-9205, USA.

Funding

AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
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Intramural NIH HHS Z99 AG999999NIA NIH HHS N01 AG012100
6 · The paper itself

Abstract

backgroundAlthough the importance of sleep on preservation of several physiological functions is well known, the relationship with the two interconnected tissues - muscle and bone is less understood.

objectivesThis study aimed to examine the association of 24-hour sleep duration with mid-thigh muscle composition and proximal femur volumetric bone mineral density (vBMD).

methods2438 men and 3326 women aged 66 to 96years, residents in the Reykjavik area, were included in this cross-sectional study. Proximal femur integral vBMD, mid-thigh muscle area and muscle attenuation were assessed with computed tomography. Sleep and nap habits were assessed using a questionnaire.

resultsWe found that after adjustment for age and BMI long sleep duration (>8h/d) was negatively associated with thigh lean area in both men (B=-2.21, 95% confidence interval (CI): -4.01, -0.40) and women (B=-2.39, 95% CI: -3.75, -1.03) and with muscle attenuation (B=-0.95, 95% CI: -1.47, -0.43) only in women. After adjustments for age, health and lifestyle factors the association between long sleep duration and muscle lean area was attenuated and became nonsignificant while associations with muscle attenuation remained marginally significant (B=-0.51, 95% CI: -1.03, -0.002). Sleep duration was not associated with proximal femur integral vBMD in the multivariate models.

conclusionLong sleep duration, particularly in old women, can affect thigh muscle attenuation (increase in intramuscular fat). Whether optimization of sleep can ameliorate age-associated intramuscular or intermuscular adipose tissue warrants further studies.

Indexed as

AgedAged, 80 and overAgingBone DensityCross-Sectional StudiesFemaleFemurHumansMaleMuscle, SkeletalSleepThighTime FactorsTomography, X-Ray ComputedComputed tomographyFat infiltrationMuscle compositionProximal femur

Identifiers

PMID28404506
PMCPMC5499246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.