Evidence map›Paper›PMID 28403939›Full record

ArticleMetabolism: clinical and experimental2017

Melanocortin 4 receptor is not required for estrogenic regulations on energy homeostasis and reproduction.

Pingwen Xu, Liangru Zhu, Kenji Saito, Yongjie Yang, Chunmei Wang, Yanlin He, Xiaofeng Yan, Ilirjana Hyseni, Qingchun Tong, Yong Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Activation of the ARCFrontiers in neural circuits · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Pingwen XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030. Electronic address: pingwenx@bcm.edu.
Liangru ZhuDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
Kenji SaitoChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Yongjie YangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Chunmei WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Yanlin HeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Xiaofeng YanChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Ilirjana HyseniChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Qingchun TongBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030.
Yong XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Electronic address: yongx@bcm.edu.
Children's Nutrition Research Center at Baylor College of Medicine · USBaylor College of Medicine · USBrown Foundation · USUnion Hospital · CN

Funding

Sim1 Neurons and Body Weight RegulationR01DK092605 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2012 to 2016
$1.7M
CNS Circuits Mediating Estrogenic Regulation on Energy and Glucose HomeostasisR01DK093587 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2011 to 2015
$1.6M
Targeting hypothalamic steroid receptor co-activator-1 to treat obesityR01DK101379 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2014 to 2017
$1.2M
Medial amygdala ERα neurocircuits in the regulation of physical activityK99DK107008 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, PINGWEN · 2016 to 2017
$178k
NIDDK NIH HHS K99 DK107008NIDDK NIH HHS R01 DK092605NIDDK NIH HHS R01 DK093587NIDDK NIH HHS R01 DK101379
6 · The paper itself

Abstract

backgroundBrain estrogen receptor-α (ERα) is essential for estrogenic regulation of energy homeostasis and reproduction. We previously showed that ERα expressed by pro-opiomelanocortin (POMC) neurons mediates estrogen's effects on food intake, body weight, negative regulation of hypothalamic-pituitary-gonadal axis (HPG axis) and fertility. RESULTS AND

conclusionsWe report here that global deletion of a key downstream receptor for POMC peptide, the melanocortin 4 receptor (MC4R), did not affect normal negative feedback regulation of estrogen on the HPG axis, estrous cyclicity and female fertility. Furthermore, loss of the MC4R did not influence estrogenic regulation on food intake and body weight. These results indicate that the MC4R is not required for estrogen's effects on metabolic and reproductive functions.

Indexed as

EstrogensHomeostasisReproductionAnimalsBody WeightEatingEnergy MetabolismFeedback, PhysiologicalFemaleMiceMice, Inbred C57BLPregnancyPro-OpiomelanocortinReceptor, Melanocortin, Type 4EstrogensPro-OpiomelanocortinReceptor, Melanocortin, Type 4Energy homeostasisEstrogenMC4RReproduction

Identifiers

PMID28403939
PMCPMC5407306
OpenAlexW2563688522

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.