ArticleMetabolism: clinical and experimental2017
A prospective study of low fasting glucose with cardiovascular disease events and all-cause mortality: The Women's Health Initiative.
Article in Metabolism: clinical and experimental, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Pooled it
- Clinical value of Lp-PLA2, LDL-C, HDL-C, hs-CRP, leukocyte, FPG and HbA1c in type 2 diabetes mellitus patients with acute ischemic stroke.Frontiers in endocrinology · 2025Article
- Association of longitudinal trajectories of fasting plasma glucose with all-cause and cardiovascular mortality among a Chinese older population: a retrospective cohort study.BMC public health · 2024Article
- Risk prediction of diabetic retinopathy based on visit-to-visit fasting blood glucose indices.Frontiers in endocrinology · 2024Article
- Random plasma glucose levels and cause-specific mortality among Chinese adults without known diabetes: an 11-year prospective study of 450,000 people.BMJ open diabetes research & care · 2021Article
- Efficient Data-Mining Algorithm for Predicting Heart Disease Based on an Angiographic Test.The Malaysian journal of medical sciences : MJMS · 2021Article
- Phenotyping the Prediabetic Population-A Closer Look at Intermediate Glucose Status and Cardiovascular Disease.International journal of molecular sciences · 2021Review
- Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study.The Korean journal of internal medicine · 2021Article
- Association Between Fasting Blood Glucose and All-Cause Mortality in a Rural Chinese Population: 15-Year Follow-Up Cohort Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2020Article
- Decreased Threshold of Fasting Serum Glucose for Cardiovascular Events: MASHAD Cohort Study.Reports of biochemistry & molecular biology · 2020Article
- The Relationship Between Fasting Blood Glucose Levels and First Ischemic Stroke in Elderly Hypertensive Patients.Risk management and healthcare policy · 2020Article
- Fasting glucose and its association with 20-year all-cause and cause-specific mortality in Chinese general population.Chronic diseases and translational medicine · 2019Article
- Association of Low Fasting Glucose and HbA1c With Cardiovascular Disease and Mortality: The MESA Study.Journal of the Endocrine Society · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundWhile there is increasing recognition of the risks associated with hypoglycemia in patients with diabetes, few studies have investigated incident cause-specific cardiovascular outcomes with regard to low fasting glucose in the general population.
objectiveWe hypothesized that low fasting glucose would be associated with cardiovascular disease risk and all-cause mortality in postmenopausal women.
methodsTo test our hypothesis, we used both continuous incidence rates and Cox proportional hazards models in 17,287 participants from the Women's Health Initiative with fasting glucose measured at baseline. Participants were separated into groups based on fasting glucose level: low (<80mg/dL), normal/reference (80-99mg/dL), impaired (100-125mg/dL), and diabetic (≥126mg/dL).
resultsParticipants were free of cardiovascular disease at enrollment, had mean age of 62years, and were 52% Caucasian, 24% African American, 8% Asian, and 12% Hispanic. Median follow-up was 15years. Graphs of continuous incidence rates compared to fasting glucose distribution exhibited evidence of a weak J-shaped association with heart failure and mortality that was predominantly due to participants with treated diabetes. Impaired and diabetic fasting glucose were positively associated with all outcomes. Associations for low fasting glucose differed, with coronary heart disease (HR=0.64 (0.42, 0.98)) significantly inverse; stroke (0.73 (0.48, 1.13)), combined cardiovascular disease (0.91 (0.73, 1.14)), and all-cause mortality (0.97 (0.79, 1.20)) null or inverse and not significant; and heart failure (1.27 (0.80, 2.02)) positive and not significant.
conclusionsFasting glucose at the upper range, but not the lower range, was significantly associated with incident cardiovascular disease and all-cause mortality.
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