Evidence map›Paper›PMID 28403873›Full record

SynthesisBMC cancer2017

Weight change during chemotherapy in breast cancer patients: a meta-analysis.

M M G A van den Berg, R M Winkels, J Th C M de Kruif, H W M van Laarhoven, M Visser, J H M de Vries, Y C de Vries, E Kampman

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Effects of a 12-week exercise-based intervention on weight management in overweight or obese breast cancer survivors: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  12. Feasibility and efficacy of a weight gain prevention intervention for breast cancer patients receiving neoadjuvant chemotherapy: a randomized controlled pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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  13. Navigating nutritional information while living with metastatic cancer: a qualitative study of patient experiences and needs.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M M G A van den BergDivision of Human Nutrition, Wageningen University, Stippeneng 4, 6708, WE, Wageningen, The Netherlands.
R M WinkelsDivision of Human Nutrition, Wageningen University, Stippeneng 4, 6708, WE, Wageningen, The Netherlands.
J Th C M de KruifDepartment of Health Sciences, VU University Amsterdam, De Boelelaan 1085, 1081, HV, Amsterdam, The Netherlands.
H W M van LaarhovenAcademic Medical Center, Medical Oncology, Meibergdreef 9, F4-224, 1105, AZ, Amsterdam, The Netherlands.
M VisserDepartment of Health Sciences, VU University Amsterdam, De Boelelaan 1085, 1081, HV, Amsterdam, The Netherlands.
J H M de VriesDivision of Human Nutrition, Wageningen University, Stippeneng 4, 6708, WE, Wageningen, The Netherlands.
Y C de VriesDivision of Human Nutrition, Wageningen University, Stippeneng 4, 6708, WE, Wageningen, The Netherlands.
E KampmanDivision of Human Nutrition, Wageningen University, Stippeneng 4, 6708, WE, Wageningen, The Netherlands. Ellen.kampman@wur.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWeight gain during chemotherapy in women with breast cancer is commonly reported. However, there are important differences between studies that examined weight change during chemotherapy; e.g. type of chemotherapy, menopausal status, time between body weight measurements and sample size. The purpose of this meta-analysis was to quantify changes in body weight during chemotherapy for women with breast cancer, taking these differences into account.

methodsWe identified relevant studies using PubMed, Scopus and Embase databases. The search was limited to human studies published in English up to and including December 2015. Only studies among women with early stage breast cancer treated with chemotherapy, with reported body weight before and after chemotherapy and type of chemotherapy were included. Random-effect models were used, and heterogeneity between studies was explored through stratified analyses and meta-regression. Sensitivity analyses were done to explore whether a specific study markedly affected the results.

resultsIn total 25 papers were found, including data from 2620 women. Overall, body weight increased during chemotherapy: 2.7 kg (95% CI 2.0, 7.5) with a high degree of heterogeneity (I

conclusionDespite the high heterogeneity, this meta-analysis shows significant weight gain during chemotherapy for women with breast cancer. Weight gain was more pronounced in papers published until 2000 and women receiving CMF as chemotherapy regime. Although weight gain after chemotherapy has decreased over the course of time, weight gain is still substantial and deserves clinical attention.

Indexed as

Antineoplastic AgentsBody WeightBreast NeoplasmsFemaleHumansRegression AnalysisWeight GainAntineoplastic AgentsBreast cancerChemotherapyMeta-analysisWeight change

Identifiers

PMID28403873
PMCPMC5389147

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.