SynthesisScandinavian journal of trauma, resuscitation and emergency medicine2017
The use of viscoelastic haemostatic assays in goal-directing treatment with allogeneic blood products - A systematic review and meta-analysis.
Synthesis in Scandinavian journal of trauma, resuscitation and emergency medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition.Critical care (London, England) · 2023Guideline
- Thromboelastography-guided therapy improves patient blood management and certain clinical outcomes in elective cardiac and liver surgery and emergency resuscitation: A systematic review and analysis.Journal of thrombosis and haemostasis : JTH · 2019Pooled it
- The use of viscoelastic haemostatic assays in non-cardiac surgical settings: a systematic review and meta-analysis.Blood transfusion = Trasfusione del sangue · 2018Pooled it
- Point-Of-Care Testing of Fibrinogen by the qLab FIB System in Patients Taking Direct Oral Anticoagulants (DOACs).International journal of laboratory hematology · 2026Article
- Early cryoprecipitate transfusion through goal-directed bleeding management in a real world setting-How important it is to focus on the fibrinogen in major obstetric Haemorrhage.Transfusion medicine (Oxford, England) · 2026Article
- Incidence of intra-abdominal hypertension after liver transplantation with temporary portocaval shunt - A prospective cohort.Clinics (Sao Paulo, Brazil) · 2026Article
- Phenotyping the Transfusion Management Experience of Trainees Using Electronic Health Records.Anesthesia and analgesia · 2026Observational
- The Viscoelastic Haemostatic Assay Landscape in Queensland, Australia: An Analysis of Use, Indications and Integration.Emergency medicine Australasia : EMA · 2025Article
- Unveiling the Hemostatic Signature of Prematurity: A Prospective Rotational Thromboelastometry-Based Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Critical trigger thresholds for hemostatic management: a narrative review of viscoelastic hemostatic assay applications.Frontiers in medicine · 2025Review
- [Perioperative coagulation management in liver transplantation: a theoretical and practical exploration].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Article
- Comparison of Two Viscoelastic Testing Devices in a Parturient Population.Journal of clinical medicine · 2024Article
- Comparison of two viscoelastic testing devices in a porcine model of surgery, hemorrhage and resuscitation.Frontiers in bioengineering and biotechnology · 2024Article
- The in-vitro influence of urea concentration on thromboelastrography in patients with and without end stage renal disease.American journal of surgery · 2023Article
- Article
- [Viscoelasticity-based point of care coagulation diagnostics in the context of resuscitation room management of severely injured and bleeding trauma patients : Diagnostics and treatment of trauma-induced coagulopathy].Unfallchirurgie (Heidelberg, Germany) · 2023Review
- Letter to the Editor Regarding "Viscoelastic Hemostatic Assays and Outcomes in Traumatic Brain Injury: A Systematic Literature Review".World neurosurgery · 2022Article
- Thromboelastography: a review for radiologists and implications on periprocedural bleeding risk.Abdominal radiology (New York) · 2022Review
- Intraoperative thromboelastography-guided transfusion in a patient with factor XI deficiency: A case report.World journal of clinical cases · 2022Article
- Hemostasis in neonatal ECMO.Frontiers in pediatrics · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundManagement of the critically bleeding patient can be encountered in many medical and surgical settings. Common for these patients is a high risk of dying from exsanguination secondary to developing coagulopathy. The purpose of this meta-analysis was to systematically review and assess randomised controlled trials (RCTs) performed on patients in acute need for blood transfusions due to bleeding to evaluate the effect of viscoelastic haemostatic assay (VHA) guidance on bleeding, transfusion requirements and mortality.
methodsPubMed and EMBASE were searched for RCTs that 1) randomised patients into receiving transfusions based on either a VHA-guided (thromboelastography [TEG] or rotational thromboelastometry [ROTEM]) algorithm (intervention group) or at the clinician's discretion and/or based on conventional coagulation tests (control group) and 2) adequately reported on the outcomes bleeding and/or transfusions and/or mortality. Data on bleeding, transfusions and mortality were extracted from each trial and included in a meta-analysis.
resultsFifteen RCTs (n = 1238 patients) were included. Nine trials referred to cardiothoracic patients, one to liver transplantation, one to surgical excision of burn wounds and one to trauma. One trial was conducted with cirrhotic patients, one with patients undergoing scoliosis surgery while one trial randomised treatment in post-partum females presenting with bleeding. The amount of transfused red blood cells (RBCs), fresh frozen plasma (FFP) and bleeding volume was found to be significantly reduced in the VHA-guided groups, whereas no significant difference was found for platelet transfusion requirements or mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.