Evidence map›Paper›PMID 28403746›Full record

ArticleThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2017

Feed-Forwardness of Spinal Networks in Posture and Locomotion.

Yury Gerasimenko, Dimitry Sayenko, Parag Gad, Chao-Tuan Liu, Niranjala J K Tillakaratne, Roland R Roy, Inessa Kozlovskaya, V Reggie Edgerton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 43 citations in OpenAlex.

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  8. Synergistic implications of combinatorial rehabilitation approaches using spinal stimulation on therapeutic outcomes in spinal cord injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
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  17. Home-Based SCONENeurotrauma reports · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Yury Gerasimenko1 Department of Integrative Biology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Dimitry Sayenko1 Department of Integrative Biology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Parag Gad1 Department of Integrative Biology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Chao-Tuan Liu1 Department of Integrative Biology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Niranjala J K Tillakaratne1 Department of Integrative Biology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Roland R Roy1 Department of Integrative Biology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Inessa Kozlovskaya2 Pavlov Institute of Physiology, St. Petersburg, Russia.
V Reggie Edgerton1 Department of Integrative Biology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USInstitute of Biomedical Problems · RUPavlov Institute of Physiology of the Russian Academy of Sciences · RU

Funding

Enabling forelimb function with agonist drug and epidural stimulation in SCIU01EB015521 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE, LU, DANIEL · 2013 to 2017
$6.0M
Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCIR01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE · 2008 to 2013
$4.9M
Spinal Epidural Electrode Array To Facilitate Standing and Stepping After SCIU01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE, GAD, PARAG · 2014 to 2018
$4.8M
NIBIB NIH HHS R01 EB007615NIBIB NIH HHS U01 EB007615NIBIB NIH HHS U01 EB015521
6 · The paper itself

Abstract

We present a new perspective on the concept of feed-forward compared to feedback mechanisms for motor control. We propose that conceptually all sensory information in real time provided to the brain and spinal cord can be viewed as a feed-forward phenomenon. We also propose that the spinal cord continually adapts to a broad array of ongoing sensory information that is used to adjust the probability of making timely and predictable decisions of selected networks that will execute a given response. One interpretation of the term feedback historically entails responses with short delays. We propose that feed-forward mechanisms, however, range in timeframes of milliseconds to an evolutionary perspective, that is, "evolutionary learning." Continuously adapting events enable a high level of automaticity within the sensorimotor networks that mediate "planned" motor tasks. We emphasize that either a very small or a very large proportion of motor responses can be under some level of conscious vs automatic control. Furthermore, we make a case that a major component of automaticity of the neural control of movement in vertebrates is located within spinal cord networks. Even without brain input, the spinal cord routinely uses feed-forward processing of sensory information, particularly proprioceptive and cutaneous, to continuously make fundamental decisions that define motor responses. In effect, these spinal networks may be largely responsible for executing coordinated sensorimotor tasks, even those under normal "conscious" control.

Indexed as

Afferent PathwaysAnimalsBrainFeedback, PhysiologicalHumansLocomotionNerve NetPostureSpinal Cordcentral pattern generationfeed-forward controlspinal automaticityspinal cord injuryspinal learning

Identifiers

PMID28403746
PMCPMC5495622
OpenAlexW2578050227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.