Evidence map›Paper›PMID 28403622›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias2017

Amyloid Positivity Using [18F]Flutemetamol-PET and Cognitive Deficits in Nondemented Community-Dwelling Older Adults.

Dustin B Hammers, Taylor J Atkinson, Bonnie C A Dalley, Kayla R Suhrie, Kevin P Horn, Kelli M Rasmussen, Britney E Beardmore, Lance D Burrell, Kevin Duff, John M Hoffman

Open access · greenAbstract read
In one paragraph

Article in American journal of Alzheimer's disease and other dementias, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Validation of HVLT-R, BVMT-R, and RBANS Learning Slope Scores along the Alzheimer's Continuum.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022
    Article
  6. Evaluation of semi-quantitative measures ofQuantitative imaging in medicine and surgery · 2022
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dustin B Hammers1 Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA.
Taylor J Atkinson1 Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA.
Bonnie C A Dalley1 Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA.
Kayla R Suhrie1 Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA.
Kevin P Horn2 Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Kelli M Rasmussen2 Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Britney E Beardmore2 Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Lance D Burrell2 Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Kevin Duff1 Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA.
John M Hoffman2 Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
University of Utah · USHuntsman Cancer Institute · US

Funding

Cognitive training and practice effects in MCIR01AG045163 · NIA · UNIVERSITY OF UTAH · PI DUFF, KEVIN M · 2014 to 2018
$2.2M
Predicting dementia with practice effectsK23AG028417 · NIA · UNIVERSITY OF UTAH · PI DUFF, KEVIN M · 2007 to 2011
$707k
NIA NIH HHS K23 AG028417NIA NIH HHS R01 AG045163
6 · The paper itself

Abstract

Little research exists examining the relationship between beta-amyloid neuritic plaque density via [18F]flutemetamol binding and cognition; consequently, the purpose of the current study was to compare cognitive performances among individuals having either increased amyloid deposition (Flute+) or minimal amyloid deposition (Flute-). Twenty-seven nondemented community-dwelling adults over the age of 65 underwent [18F]flutemetamol amyloid-positron emission tomography imaging, along with cognitive testing using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and select behavioral measures. Analysis of variance was used to identify the differences among the cognitive and behavioral measures between Flute+/Flute- groups. Flute+ participants performed significantly worse than Flute- participants on RBANS indexes of immediate memory, language, delayed memory, and total scale score, but no significant group differences in the endorsed level of depression or subjective report of cognitive difficulties were observed. Although these results are preliminary, [18F]flutemetamol accurately tracks cognition in a nondemented elderly sample, which may allow for better prediction of cognitive decline in late life.

Indexed as

Aniline CompoundsBenzothiazolesRadiopharmaceuticalsAgedAged, 80 and overAmyloid beta-PeptidesCognitive AgingCognitive DysfunctionFemaleHumansMalePositron-Emission TomographyAmyloid beta-PeptidesAniline CompoundsBenzothiazolesflutemetamolRadiopharmaceuticalsamyloid imagingclinical trialscognitionRBANS

Identifiers

PMID28403622
PMCPMC5749186
OpenAlexW2607202766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.