ArticlePloS one2017
Association of vitamin D deficiency, season of the year, and latent tuberculosis infection among household contacts.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Association of variant vitamin statuses and tuberculosis development: a systematic review and meta-analysis.Annals of medicine · 2024Pooled it
- Prevalence of non-communicable diseases among household contacts of people with tuberculosis: A systematic review and individual participant data meta-analysis.Tropical medicine & international health : TM & IH · 2024Pooled it
- Vitamin D and the risk of latent tuberculosis infection: a systematic review and meta-analysis.BMC pulmonary medicine · 2022Pooled it
- Evaluation of host-immune biomarker signatures as multiplex qPCR diagnostic assays: a pilot study toward meeting WHO target product profiles for TB diagnosis in India.Frontiers in tuberculosis · 2025Article
- Analyzing the seasonality of tuberculosis case notifications in the UK, 2000-2018.Epidemiology and infection · 2024Article
- Effects of Climate, Sun Exposure, and Dietary Intake on Vitamin D Concentrations in Pregnant Women: A Population-Based Study.Nutrients · 2023Article
- Seasonality and Delirium Tremens in Hospitalized Patients with Alcohol Dependence Syndrome.European addiction research · 2023Article
- An influence of dew point temperature on the occurrence of Mycobacterium tuberculosis disease in Chennai, India.Scientific reports · 2022Article
- Hypovitaminosis D among newly diagnosed pulmonary TB patients and their household contacts in Uganda.Scientific reports · 2022Article
- Association of Vitamin D Deficiency With Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis.Cureus · 2021Review
- The Moderate Correlation Between 25(OH)D Serum and Saliva in Healthy People with Low Vitamin D Intake.International journal of general medicine · 2021Article
- Does sunlight drive seasonality of TB in Vietnam? A retrospective environmental ecological study of tuberculosis seasonality in Vietnam from 2010 to 2015.BMC infectious diseases · 2020Article
- Levels of vitamin D-associated cytokines distinguish between active and latent tuberculosis following a tuberculosis outbreak.BMC infectious diseases · 2019Article
- Trend Analysis And Seasonality Of Tuberculosis Among Patients At The Hiwot Fana Specialized University Hospital, Eastern Ethiopia: A Retrospective Study.Risk management and healthcare policy · 2019Article
- Article
- Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.PLoS neglected tropical diseases · 2018Article
- Serum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners.Scientific reports · 2018Article
- Article
- Vitamin D supplementation as a control program against latent tuberculosis infection in Korean high school students.Epidemiology and health · 2018Article
- Seasonality of tuberculosis in the Republic of Korea, 2006-2016.Epidemiology and health · 2018Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesVitamin D (VD) enhances the immune response against Mycobacterium tuberculosis in vitro, and VD deficiency has been described in patients with active tuberculosis (TB). However, the role of hypovitaminosis D in the pathogenesis of early TB infection acquisition is unclear. We aimed to evaluate the association of VD deficiency, season of the year, and latent TB infection in household contacts (HHC), given that this is a potentially modifiable condition often related to nutritional deficiencies and lack of sun exposure.
methodsWe prospectively enrolled new pulmonary TB cases (n = 107) and their HHC (n = 144) over a 2-year period in Santiago, Chile. We compared plasma 25-hydroxycholecalciferol (25OHD) levels and examined the influence of season, ethnic background, living conditions, and country of origin.
resultsOver 77% of TB cases and 62.6% of HHC had VD deficiency (<20 ng/ml). Median 25OHD concentration was significantly lower in TB cases than in HHC (11.7 vs. 18.2 ng/ml, p<0.0001). Migrants HHC had lower 25OHD levels than non-migrants (14.6 vs. 19.0 ng/ml, p = 0.026), and a trend towards a higher burden of latent TB infection (52.9% vs. 35.2%, p = 0.066). Multivariate analysis found VD deficiency in HHC was strongly associated with being sampled in winter/spring (adOR 25.68, 95%CI 7.35-89.7), corresponding to the seasons with lowest solar radiation exposure. Spring enrollment-compared with other seasons-was the chief risk factor for latent TB infection in HHC (adOR 3.14, 95%CI 1.28-7.69).
conclusionsHypovitaminosis D was highly prevalent in TB cases and also in HHC. A marked seasonality was found for both VD levels and latent TB in HHC, with winter being the season with lowest VD levels and spring the season with the highest risk of latent TB infection.
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