SynthesisMedicine2017
Subclinical hypothyroidism and the risk of chronic kidney disease in T2D subjects: A case-control and dose-response analysis.
Synthesis in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis.BMJ open · 2019Pooled it
- Hypothyroidism and Adverse Endpoints in Diabetic Patients: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2019Pooled it
- The relationship between thyroid dysfunction, cardiovascular morbidity and mortality in type 2 diabetes: The Fremantle Diabetes Study Phase II.Acta diabetologica · 2022Trial
- Interrelationship between thyroid hormones and reduced renal function, a review article.Thyroid research · 2024Article
- Relationship between subclinical hypothyroidism and distal-symmetric diabetic polyneuropathy in type 2 diabetes mellitus referred to Kosar Hospital in Semnan and related indicators in 2019-2020.Journal of family medicine and primary care · 2022Article
- Effect of Subclinical Hypothyroidism on the Association between Hemoglobin A1c and Reduced Renal Function: A Prospective Study.Diagnostics (Basel, Switzerland) · 2022Article
- Serum Antithyroglobulin Antibody Levels Are Associated with Diabetic Retinopathy among Euthyroid Type 2 Diabetes Patients: A Hospital-Based, Retrospective Study.Journal of diabetes research · 2022Article
- Relation of kidney function and homocysteine in patients with hypothyroidism.Endocrine connections · 2021Article
- A Pilot Trial on the Effect of Levothyroxine on Proteinuria in Patients With Advanced CKD.Kidney international reports · 2021Article
- Association between hypothyroidism and chronic kidney disease observed among an adult population 55 years and older.Medicine · 2020Observational
- Hypothyroidism and Kidney Function: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2020Article
- Thyroid Parameters and Kidney Disorder in Type 2 Diabetes: Results from the METAL Study.Journal of diabetes research · 2020Article
- Article
- Correlation of Thyroid Hormone Profile with Biochemical Markers of Renal Function in Patients with Undialyzed Chronic Kidney Disease.Indian journal of endocrinology and metabolismArticle
- Protocol and Methods: Role of Levothyroxine on the Progression of Chronic Kidney Disease in Subclinical Hypothyroid Populations (LP-CKD) - A Multicenter Randomized Controlled Trial.Indian journal of nephrologyArticle
- TRPV2 POLYMORPHISMS INCREASE OR REDUCE THE RISK OF TYPE 2 DIABETES - HASHIMOTO THYROIDITIS COMORBIDITY.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
- Retraction · 2023-03-10Duplication of/in Article · Ethical Violations by Author · False/Forged Authorship · Falsification/Fabrication of Data ·
- Retracted
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence indicated a positive association between subclinical hypothyroidism (SCH) and cardiovascular diseases. But the relationship between SCH and chronic kidney diseases (CKD) remains unclear. A case-control study was performed to ascertain this relationship followed by a meta-analysis. In this hospital-based, case-control study, we recruited 3270 type 2 diabetic patients with euthyroidism and 545 type 2 diabetic patients with SCH. All English studies were searched upon the relationship between SCH and CKD up to October 2016. Meta-analysis was performed using STATA 13.0 software. Our case-control study indicated an association between SCH and CKD in patients with type 2 diabetes [OR (95% CI): 1.22 (1.09-1.36)]. Five observational studies reporting risk of CKD in SCH individuals were enrolled. A significant relationship between SCH and CKD was shown [pooled OR 1.80, (95% CI) 1.38-2.35]. Among normal TSH range, individuals with TSH ≥3.0 μIU/ml had a significantly higher rate of CKD (Fisher exact test, P = 0.027). Dose-response linear increase of CKD events was explored [pooled OR 1.09 (95% CI): 1.03-1.16 per1 mIU/L increase of TSH]. The present evidence suggests that SCH is probably a significant risk factor of CKD in T2D. Linear trend is shown between TSH elevation and CKD in T2D. This relationship between serum TSH and renal impairment in type 2 diabetic patients needs further studies to investigate.
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