ArticleThe Pediatric infectious disease journal2017
Clinical and Microbiologic Characteristics of Early-onset Sepsis Among Very Low Birth Weight Infants: Opportunities for Antibiotic Stewardship.
Article in The Pediatric infectious disease journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Determinants of the Very Low-Birth-Weight Infant's Intestinal Microbiome: A Systematic Review.The Journal of perinatal & neonatal nursingPooled it
- Risk assessment of early-onset sepsis in extremely preterm infants: implications for antibiotic stewardship.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Risk Factors and Outcomes of Early-Onset Sepsis in Very Preterm Infants: Results from the Thai Neonatal Registry (ThaiNy).Antibiotics (Basel, Switzerland) · 2026Article
- Blood cultures to define neonatal early-onset sepsis: why not enough for clinical care?Pediatric research · 2026Article
- Implementation of the early-onset sepsis calculator in a tertiary care NICU.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Blood volume collected for cultures in infants with suspected neonatal sepsis.Journal of perinatology : official journal of the California Perinatal Association · 2024Observational
- Predictive factors for perinatal bacterial transmission from colonized mothers to delivered very-low-birth-weight infants: a retrospective cohort study.Scientific reports · 2024Article
- 16S rDNA Sequencing for Bacterial Identification in Preterm Infants with Suspected Early-Onset Neonatal Sepsis.Tropical medicine and infectious disease · 2024Article
- Association of delivery risk phenotype with early-onset sepsis in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Early antibiotic exposure in very-low birth weight infants and infection risk at 3-7 days after birth.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Effects of prophylactic antibiotics administration on barrier properties of intestinal mucosa and mucus from preterm born piglets.Drug delivery and translational research · 2023Article
- Restrictive Use of Empirical Antibiotics Is Associated with Improved Short Term Outcomes in Very Low Birth Weight Infants: A Single Center, Retrospective Cohort Study from China.Antibiotics (Basel, Switzerland) · 2023Article
- Patterns of Infections among Extremely Preterm Infants.Journal of clinical medicine · 2023Article
- Ampicillin dosing in premature infants for early-onset sepsis: exposure-driven efficacy, safety, and stewardship.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Article
- Optimal dose of cefotaxime in neonates with early-onset sepsis: A developmental pharmacokinetic model-based evaluation.Frontiers in pharmacology · 2022Article
- Practice Summary of Antimicrobial Therapy for Commonly Encountered Conditions in the Neonatal Intensive Care Unit: A Canadian Perspective.Frontiers in pediatrics · 2022Review
- Clinical Early-Onset Sepsis Is Equally Valid to Culture-Proven Sepsis in Predicting Outcome in Infants after Preterm Rupture of Membranes.Journal of clinical medicine · 2021Article
- Phenotyping preterm infants at birth to predict infection risk.Pediatric research · 2021Article
- [A clinical analysis of sepsis in very low birth weight infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMost very low birth weight (VLBW, birth weight <1500 g) infants receive empiric antibiotics for risk of early-onset sepsis (EOS). The objective of this study was to determine the characteristics of VLBW infants with culture-confirmed EOS at a single center during 25 years and to identify opportunities for antibiotic stewardship.
methodsRetrospective cohort study includes VLBW infants admitted from 1990 to 2015. EOS was defined as isolation of a pathogen in blood or cerebrospinal fluid culture obtained at <72 hours of age. Clinical and microbiologic characteristics of EOS case infants were obtained by review of medical, laboratory and administrative records. Blood culture, antibiotic initiation and maternal discharge code data were available for all VLBW infants born between 1999 and 2013.
resultOne-hundred nine EOS cases (20.5/1000 VLBW births) occurred during the study period. Preterm labor, preterm rupture of membranes and/or the obstetrical diagnosis of chorioamnionitis were present in 106/109 cases (97%). Obligate anaerobic organisms accounted for 16% of cases. Time to culture positivity was 36 hours for 88% and 48 hours for 98% of cases. From 1999 to 2013, 97% of VLBW infants were evaluated for EOS and 90% administered empiric antibiotics; 22% of these infants were born by cesarean section to mothers with preeclampsia and without preterm labor or chorioamnionitis and had a 12-fold lower incidence of EOS compared with the remaining infants.
conclusionDecisions to initiate and discontinue empiric antibiotics among VLBW infants can be informed by the delivery characteristics of infected infants and by local microbiologic data.
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