Evidence map›Paper›PMID 28402889›Full record

ArticleBiophysical journal2017

Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions.

Janina R Lange, Claus Metzner, Sebastian Richter, Werner Schneider, Monika Spermann, Thorsten Kolb, Graeme Whyte, Ben Fabry

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 58 citations in OpenAlex.

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  13. Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Janina R LangeBiophysics Group, Department of Physics, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Claus MetznerBiophysics Group, Department of Physics, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Sebastian RichterBiophysics Group, Department of Physics, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Werner SchneiderBiophysics Group, Department of Physics, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Monika SpermannBiophysics Group, Department of Physics, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Thorsten KolbDivision of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Graeme WhyteIB3: Institute of Biological Chemistry, Biophysics and Bioengineering, Department of Physics, Heriot-Watt University, Edinburgh, United Kingdom.
Ben FabryBiophysics Group, Department of Physics, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany. Electronic address: bfabry@biomed.uni-erlangen.de.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEGerman Cancer Research Center · DEHeriot-Watt University · GB

Funding

RESISTANCE OF THE CELL TO SHAPE DISTORTION--BASIS OF CYTOSKELETAL MECHANICSP01HL033009 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ROGERS, RICK · 1985 to 2005
$10.0M
NHLBI NIH HHS P01 HL033009
6 · The paper itself

Abstract

We describe a quantitative, high-precision, high-throughput method for measuring the mechanical properties of cells in suspension with a microfluidic device, and for relating cell mechanical responses to protein expression levels. Using a high-speed (750 fps) charge-coupled device camera, we measure the driving pressure Δp, maximum cell deformation ε

Indexed as

Biomechanical PhenomenaCellsCells, CulturedHumansK562 CellsLab-On-A-Chip DevicesMicrotechnologyPoloxamerReproducibility of ResultsStress, MechanicalTime FactorsTrypsinPoloxamerTrypsin

Identifiers

PMID28402889
PMCPMC5389962
OpenAlexW2606826911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.