Evidence map›Paper›PMID 28402885›Full record

ArticleBiophysical journal2017

Line Tension Controls Liquid-Disordered + Liquid-Ordered Domain Size Transition in Lipid Bilayers.

Rebecca D Usery, Thais A Enoki, Sanjula P Wickramasinghe, Michael D Weiner, Wen-Chyan Tsai, Mary B Kim, Shu Wang, Thomas L Torng, David G Ackerman, Frederick A Heberle and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Rebecca D UseryDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York.
Thais A EnokiDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York.
Sanjula P WickramasingheDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York; Department of Biochemistry and Biophysics at the University of Pennsylvania, Philadelphia, Pennsylvania.
Michael D WeinerDepartment of Physics, Cornell University, Ithaca, New York.
Wen-Chyan TsaiDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York.
Mary B KimDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York; Department of Medicine, Baylor College of Medicine, Houston, Texas.
Shu WangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York; Harvard Medical School Library of Integrated Network-based Cellular Signatures Center and Laboratory of Systems Pharmacology, Harvard University, Boston, Massachusetts.
Thomas L TorngDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York; Department of Biochemistry, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire.
David G AckermanDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York; Scientific Computing, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia.
Frederick A HeberleJoint Institute for Biological Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee; Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, Tennessee.
John KatsarasBiology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; Department of Physics and Astronomy, University of Tennessee, Knoxville, Tennessee.
Gerald W FeigensonDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York. Electronic address: gwf3@cornell.edu.

Funding

TR&D 4 for ACERT, 2017-2021 funding periodP41GM103521 · NIGMS · CORNELL UNIVERSITY · PI FREED, JACK H · 2012 to 2021
$11.7M
TRAINING IN MOLECULAR PHYSICS OF BIOLOGICAL SYSTEMST32GM008267 · NIGMS · CORNELL UNIVERSITY ITHACA · PI WANG, MICHELLE D. · 1988 to 2021
$9.6M
Control of Retrovirus Assembly by Membrane Lipid Thermodynamic Activity.R01GM105684 · NIGMS · CORNELL UNIVERSITY · PI FEIGENSON, GERALD WILLIAM · 2013 to 2016
$1.2M
NIGMS NIH HHS P41 GM103521NIGMS NIH HHS R01 GM105684NIGMS NIH HHS T32 GM008267
6 · The paper itself

Abstract

To better understand animal cell plasma membranes, we studied simplified models, namely four-component lipid bilayer mixtures. Here we describe the domain size transition in the region of coexisting liquid-disordered (Ld) + liquid-ordered (Lo) phases. This transition occurs abruptly in composition space with domains increasing in size by two orders of magnitude, from tens of nanometers to microns. We measured the line tension between coexisting Ld and Lo domains close to the domain size transition for a variety of lipid mixtures, finding that in every case the transition occurs at a line tension of ∼0.3 pN. A computational model incorporating line tension and dipole repulsion indicated that even small changes in line tension can result in domains growing in size by several orders of magnitude, consistent with experimental observations. We find that other properties of the coexisting Ld and Lo phases do not change significantly in the vicinity of the abrupt domain size transition.

Indexed as

Biophysical PhenomenaPhase TransitionElectron Spin Resonance SpectroscopyLipid BilayersMolecular Dynamics SimulationNeutron DiffractionScattering, Small AngleLipid Bilayers

Identifiers

PMID28402885
PMCPMC5390056

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.