Evidence map›Paper›PMID 28402854›Full record

ArticleCell reports2017

In Vivo Interplay between p27

Bradley J Walters, Emily Coak, Jennifer Dearman, Grace Bailey, Tetsuji Yamashita, Bryan Kuo, Jian Zuo

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 147 citations in OpenAlex.

  1. Article
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  7. Review
  8. EDNRB2 regulates fate, migration, and maturation of hair cell precursors in regenerating avian auditory epithelium explants.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
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  11. Article
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  14. Article
  15. AAV-regulatedMolecular therapy. Nucleic acids · 2024
    Article
  16. Reprogramming withPNAS nexus · 2024
    Article
  17. Review
  18. Metabolic Profiling of Cochlear Organoids Identifies α-Ketoglutarate and NADAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  19. AAV-mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bradley J WaltersDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Emily CoakDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jennifer DearmanDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Grace BaileyDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tetsuji YamashitaDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Bryan KuoDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jian ZuoDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: jian.zuo@stjude.org.
St. Jude Children's Research Hospital · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
GENETIC ANALYSIS OF MAMMALIAN HEARING SENSITIVITYR01DC006471 · NIDCD · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ZUO, JIAN · 2004 to 2013
$3.5M
Genetic control of cellular conversion in the mature cochleaR01DC015010 · NIDCD · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ZUO, JIAN · 2016 to 2020
$2.3M
Discovery of In Vivo Small Molecules for Hearing Protection Against Cisplatin and NoiseR01DC015444 · NIDCD · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ZUO, JIAN · 2016 to 2018
$1.6M
Drug discovery for hair cell regeneration in adult mammalian cochleaeR21DC013879 · NIDCD · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ZUO, JIAN · 2014 to 2015
$479k
NCI NIH HHS P30 CA021765NIDCD NIH HHS R01 DC006471NIDCD NIH HHS R01 DC015010NIDCD NIH HHS R01 DC015444NIDCD NIH HHS R21 DC013879
6 · The paper itself

Abstract

Hearing loss is widespread and persistent because mature mammalian auditory hair cells (HCs) are nonregenerative. In mice, the ability to regenerate HCs from surrounding supporting cells (SCs) declines abruptly after postnatal maturation. We find that combining p27

Indexed as

AnimalsAnimals, NewbornBasic Helix-Loop-Helix ProteinsCell ProliferationCochleaCyclin-Dependent Kinase Inhibitor p27GATA3 Transcription FactorGene Expression Regulation, DevelopmentalHair Cells, AuditoryHearing LossHomeodomain ProteinsHumansMiceRegenerationSignal TransductionTranscription Factor Brn-3CAtoh1 protein, mouseBasic Helix-Loop-Helix ProteinsCdkn1b protein, mouseCyclin-Dependent Kinase Inhibitor p27Gata3 protein, mouseGATA3 Transcription FactorHomeodomain ProteinsPou4f3 protein, mouseTranscription Factor Brn-3Cagingcancercochleadevelopmentdifferentiationhearingproliferationregenerationsensory

Identifiers

PMID28402854
PMCPMC5423718
OpenAlexW2607456615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.