Evidence map›Paper›PMID 28402853›Full record

ArticleCell reports2017

Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification.

Svetlana Petruk, Samanta A Mariani, Marco De Dominici, Patrizia Porazzi, Valentina Minieri, Jingli Cai, Lorraine Iacovitti, Neal Flomenberg, Bruno Calabretta, Alexander Mazo

Abstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Fibrosis-the tale of H3K27 histone methyltransferases and demethylases.Frontiers in cell and developmental biology · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. PRC2 is high maintenance.Genes & development · 2019
    Review
  17. Article
  18. Modeling the Hematopoietic Landscape.Frontiers in cell and developmental biology · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Svetlana PetrukDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Samanta A MarianiDepartment of Cancer Biology, Sidney Kimmel Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Marco De DominiciDepartment of Cancer Biology, Sidney Kimmel Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Patrizia PorazziDepartment of Cancer Biology, Sidney Kimmel Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Valentina MinieriDepartment of Cancer Biology, Sidney Kimmel Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Jingli CaiDepartment of Neuroscience, Sidney Kimmel Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lorraine IacovittiDepartment of Neuroscience, Sidney Kimmel Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Neal FlomenbergDepartment of Medical Oncology, Sidney Kimmel Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Bruno CalabrettaDepartment of Cancer Biology, Sidney Kimmel Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: bruno.calabretta@jefferson.edu.
Alexander MazoDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: alexander.mazo@jefferson.edu.

Funding

TRANSCRIPTIONAL REGULATION BY EPIGENETIC FACTORSR01GM075141 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI MAZO, ALEXANDER M · 2005 to 2021
$4.9M
Using reporter human iPS cells to study fate, function and Parkinson's diseaseR01NS075839 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI IACOVITTI, LORRAINE · 2012 to 2021
$3.8M
The Role of the De-condensed Structure of Nascent Chromatin During T Cell DifferentiationR01AI125650 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI IACOVITTI, LORRAINE, MAZO, ALEXANDER M · 2017 to 2021
$3.1M
The role of chromatin structure in differentiation of hematopoietic stem cellsR01HL127895 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CALABRETTA, BRUNO, MAZO, ALEXANDER M · 2016 to 2019
$2.1M
NHLBI NIH HHS R01 HL127895NIAID NIH HHS R01 AI125650NIGMS NIH HHS R01 GM075141NINDS NIH HHS R01 NS075839
6 · The paper itself

Abstract

The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34

Indexed as

AnimalsAntigens, CD34CCAAT-Enhancer-Binding Protein-alphaCell DifferentiationCell LineageChromatinDNA ReplicationGATA1 Transcription FactorHematopoiesisHematopoietic Stem CellsHumansJumonji Domain-Containing Histone DemethylasesMiceProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Trans-ActivatorsAntigens, CD34CCAAT-Enhancer-Binding Protein-alphaChromatinGata1 protein, mouseGATA1 Transcription FactorJumonji Domain-Containing Histone DemethylasesKdm6b protein, mouseProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Trans-ActivatorsDNA replicationH3K27me3hematopoietic progenitorsHMTsKDMsmyeloid and erythroid differentiationnascent chromatinnascent DNAtranscription factors

Identifiers

PMID28402853
PMCPMC5408750

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.