ReviewVirulence2017
Hypervirulence and hypermucoviscosity: Two different but complementary Klebsiella spp. phenotypes?
Review in Virulence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 233 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
233 citing papers in PubMed, 3 syntheses or guidelines pooled it, 342 citations in OpenAlex.
- Hypervirulent Klebsiella pneumoniae Infections: A Systematic Review of Clinical, Microbiological, and Outcome Data From Reported Cases.MicrobiologyOpen · 2026Pooled it
- Systematic review and meta-analysis of the potential effects of endophytic bacteria Klebsiella on plant growth promotion and biocontrol of pathogens.World journal of microbiology & biotechnology · 2025Pooled it
- A systematic review of hypervirulentFrontiers in medicine · 2025Pooled it
- Phenotypic screening of hypervirulentMicrobiology spectrum · 2026Article
- HypervirulentOpen forum infectious diseases · 2026Article
- Distribution of mrk genes among uopathogenic Klebsiella pneumoniae.Journal of applied genetics · 2026Article
- A rapid molecular assay for the detection of hypervirulentMicrobiology spectrum · 2026Article
- Article
- Hypermucoviscosity inJournal of bacteriology · 2026Review
- A Case Report of Endogenous Endophthalmitis Associated With a Pyogenic Liver Abscess Caused by Hypervirulent Klebsiella pneumoniae.Immunity, inflammation and disease · 2026Article
- Molecular Epidemiology ofMicroorganisms · 2026Article
- Atypical ocular and vascular manifestations ofRadiology case reports · 2026Article
- Two case reports on the identification and management of hypervirulentASM case reports · 2026Article
- Emergence and Genomic Characterization of a Hypervirulent Klebsiella pneumoniae Isolate From a New Clone in Brazil.Microbiology and immunology · 2026Article
- Emergence of hypervirulent Klebsiella pneumoniae ST111 with a novel virulence plasmid causing pyogenic liver abscess.BMC microbiology · 2026Article
- Article
- H-NS Regulates the Virulence ofMicroorganisms · 2026Article
- Clinical characteristics and molecular evolution of ST11-KL64 carbapenem-resistant hypervirulentMicrobiology spectrum · 2026Article
- Molecular detection of hypervirulent Klebsiella pneumoniae (hvKp) in Egyptian poultry.BMC veterinary research · 2026Article
- Article
173 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the hypermucoviscous variants of Klebsiella pneumoniae were first reported, many cases of primary liver abscesses and other invasive infections caused by this pathogen have been described worldwide. Hypermucoviscosity is a phenotypic feature characterized by the formation of a viscous filament ≥5 mm when a bacterial colony is stretched by a bacteriological loop; this is the so-called positive string test. Hypermucoviscosity appears to be associated with this unusual and aggressive type of infection, and therefore, the causal strains are considered hypervirulent. Since these first reports, the terms hypermucoviscosity and hypervirulence have often been used synonymously. However, new evidence has suggested that hypermucoviscosity and hypervirulence are 2 different phenotypes that should not be used synonymously. Moreover, it is important to establish that a negative string test is insufficient in determining whether a strain is or is not hypervirulent. On the other hand, hypervirulence- and hypermucoviscosity-associated genes must be identified, considering that these phenotypes correspond to 2 different phenomena, regardless of whether they can act in synergy under certain circumstances. Therefore, it is essential to quickly identify the genetic determinants behind the hypervirulent phenotype to develop effective methodologies that can diagnose in a prompt and effective way these hypervirulent variants of K. pneumoniae.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.