Evidence map›Paper›PMID 28402694›Full record

ArticleOphthalmic epidemiology2017

Serum Phosphate and Retinal Microvascular Changes: The Multi-Ethnic Study of Atherosclerosis and the Beaver Dam Eye Study.

Rupal Mehta, Alexander Hodakowski, Xuan Cai, Kris E Lee, Bryan R Kestenbaum, Ian H de Boer, Amani Fawzi, Tien Yin Wong, Joachim Ix, Barbara Klein and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmic epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Rupal Mehtaa Division of Nephrology , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
Alexander Hodakowskib Center for Translational Metabolism and Health, Institute of Public Health and Medicine, Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
Xuan Caib Center for Translational Metabolism and Health, Institute of Public Health and Medicine, Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
Kris E Leed Ocular Epidemiology Research Group, University of Wisconsin-Madison , Madison , WI , USA.
Bryan R Kestenbaume Division of Nephrology , University of Washington , Seattle , WA , USA.
Ian H de Boere Division of Nephrology , University of Washington , Seattle , WA , USA.
Amani Fawzif Department of Ophthalmology , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
Tien Yin Wongg Vitreo-Retinal Department , Singapore National Eye Centre , Singapore , Singapore.
Joachim Ixh Division of Nephrology , University of California San Diego School of Medicine , San Diego , CA , USA.
Barbara Kleind Ocular Epidemiology Research Group, University of Wisconsin-Madison , Madison , WI , USA.
Ronald Kleind Ocular Epidemiology Research Group, University of Wisconsin-Madison , Madison , WI , USA.
Tamara Isakovaa Division of Nephrology , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
Northwestern University · USUniversity of Wisconsin–Madison · USUniversity of Washington · USSingapore National Eye Center · SGUniversity of California, San Diego · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
THE EPIDEMIOLOGY OF AGE-RELATED OCULAR DISEASEU10EY006594 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BARBARA EDEN · 1987 to 2018
$17.3M
Phosphorus and Vitamin D Metabolism and Cardiovascular Outcomes: The multi-ethniR01HL096875 · NHLBI · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H, KESTENBAUM, BRYAN R · 2010 to 2019
$5.2M
Vitamin D Catabolism in Chronic Kidney DiseaseR01DK099199 · NIDDK · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H · 2014 to 2018
$3.2M
Impact of phosphate and FGF23 reduction on intermediate end points in CKDR01DK102438 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ISAKOVA, TAMARA · 2014 to 2018
$3.0M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Functional Retinal Imaging to Monitor Pharmaco-Therapies in Diabetic RetinopathyDP3DK108248 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FAWZI, AMANI A, ZHANG, HAO F · 2015 to 2015
$1.9M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
Cardiac Outcomes Associated with Renal OsteodystrophyK23DK063274 · NIDDK · UNIVERSITY OF WASHINGTON · PI KESTENBAUM, BRYAN R · 2003 to 2007
$643k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NEI NIH HHS U10 EY006594NHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL096875NIDDK NIH HHS DP3 DK108248NIDDK NIH HHS K23 DK063274NIDDK NIH HHS R01 DK099199NIDDK NIH HHS R01 DK102438
6 · The paper itself

Abstract

purposeHigher levels of serum phosphate are strongly linked to increased risk of cardiovascular disease and therapies aimed to lower serum phosphate are employed in the management of patients with chronic kidney disease (CKD). Data are limited, however, on serum phosphate as a risk factor for microvascular disease in community-based populations. It is important to determine the impact of novel risk factors, such as phosphate, on the microvasculature.

methodsWe conducted a prospective study of 3919 individuals in the Multi-Ethnic Study of Atherosclerosis (MESA) and 3544 individuals in the Beaver Dam Eye Study (BDES) to test the associations of serum phosphate with retinopathy and retinal vessel caliber, and change in retinopathy severity and change in retinal vessel caliber.

resultsMean (standard deviation) serum phosphate was 3.66 (0.52) mg/dl in the MESA and 3.77 (0.55) mg/dl in the BDES. In multivariable adjusted models, phosphate was significantly associated with prevalent retinopathy in the MESA (Odds Ratio [OR] per 1 mg/dl increase in phosphate, 1.22; Confidence Interval [CI] 1.02-1.47) and the BDES (OR 1.06; CI 1.01-1.11). In stratified analyses, these relationships were even stronger and only seen in individuals with diabetes in both the MESA (OR 1.81; CI 1.30-2.53) and the BDES (OR 1.16; CI 1.05-1.29). Phosphate was not associated with incident or change in retinopathy severity, nor any retinal caliber outcome.

conclusionsAmong community-living individuals with low prevalence of CKD, higher serum phosphate was associated with prevalent retinopathy in individuals with diabetes. Further longitudinal assessments in patients with diabetes necessitate further investigation.

Indexed as

EthnicityMicrocirculationAdultAgedAged, 80 and overAtherosclerosisBiomarkersCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPhosphatesPrevalenceProspective StudiesBiomarkersPhosphatesDiabetesmicrovascular diseasephosphateretinopathy

Identifiers

PMID28402694
PMCPMC5844221
OpenAlexW2605449672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.