Evidence map›Paper›PMID 28402597›Full record

ArticleAmerican journal of medical genetics. Part A2017

Gene-gene interaction of single nucleotide polymorphisms in 16p13.3 may contribute to the risk of non-syndromic cleft lip with or without cleft palate in Chinese case-parent trios.

Dongjing Liu, Hong Wang, Holger Schwender, Mary L Marazita, Zhuqing Wang, Yuan Yuan, Ping Wang, Kung Yee Liang, Yah Huei Wu-Chou, Mengying Wang and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Dongjing LiuSchool of Public Health, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-9520-7789
Hong WangSchool of Public Health, Peking University, Beijing, China.
Holger SchwenderMathematical Institute, Heinrich Heine University Duesseldorf, Duesseldorf, Germany.
Mary L MarazitaCenter for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Zhuqing WangSchool of Public Health, Peking University, Beijing, China.
Yuan YuanSchool of Public Health, Peking University, Beijing, China.
Ping WangBeijing Center for Disease Prevention and Control, Beijing, China.
Kung Yee LiangNational Yang-Ming University, Taipei, Taiwan.
Yah Huei Wu-ChouChang Gung Memorial Hospital, Taoyuan, Taiwan.
Mengying WangSchool of Public Health, Peking University, Beijing, China.
Bing ShiState Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Chengdu, China.
Hongping ZhuSchool of Stomatology, Peking University, Beijing, China.
Tao WuSchool of Public Health, Peking University, Beijing, China.
Terri H BeatySchool of Public Health, Johns Hopkins University, Baltimore, Maryland.
Peking University · CNBeijing Center for Disease Prevention and Control · CNHeinrich Heine University Düsseldorf · DEJohns Hopkins University · USNational Yang Ming Chiao Tung University · TWSichuan University · CNTaoyuan Chang Gung Memorial Hospital · TWUniversity of Pittsburgh · US

Funding

Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7M
PHENOTYPE AND GENETICS IN OROFACIAL CLEFT FAMILIESP50DE016215 · NIDCR · UNIVERSITY OF IOWA · PI LOVETT, MICHAEL · 2004 to 2008
$10.1M
Molecular Genetic Epidemiology of Cleft Lip and PalateR37DE008559 · NIDCR · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 2004 to 2013
$6.8M
International Genetic Epidemiology of Oral CleftsR01DE014581 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI BEATY, TERRI H · 2004 to 2013
$6.6M
International Consortium to Identify Genes and Interactions Controlling Oral ClefU01DE018993 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI BEATY, TERRI H · 2007 to 2008
$1.6M
GENETIC MAPPING STUDIES OF ORAL-FACIAL CLEFTS IN CHINAR01DE009886 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARAZITA, MARY L · 1992 to 2002
$1.0M
Nutrition and Oral Clefts in Asia: Planning GrantR21DE016877 · NIDCR · UTAH STATE UNIVERSITY · PI MUNGER, RONALD G · 2009 to 2010
$381k
Planning International Orofacial Cleft Genetic StudiesR21DE016930 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L · 2006 to 2007
$293k
NIDCR NIH HHS P50 DE016215NIDCR NIH HHS R01 DE009886NIDCR NIH HHS R01 DE014581NIDCR NIH HHS R01 DE016148NIDCR NIH HHS R21 DE016877NIDCR NIH HHS R21 DE016930NIDCR NIH HHS R37 DE008559NIDCR NIH HHS U01 DE018993
6 · The paper itself

Abstract

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect with a complex and heterogeneous etiology. A recent genome-wide association study (GWAS) among Chinese populations has identified a new region at 16p13.3 as being associated with NSCL/P, which requires further replication. Here, we attempted to replicate and further clarify the genetic association between this region and NSCL/P, as well as testing for potential gene-gene (G × G) and gene-environment (G × E) interactions. We conducted transmission disequilibrium tests on 69 single nucleotide polymorphisms (SNPs) mapping to 16p13.3 among 806 Chinese case-parent trios ascertained through an international consortium where a GWAS of oral clefts was conducted. G × G, as well as G × E interactions involving maternal environmental tobacco smoke (ETS) and multivitamin supplementation, were explored using conditional logistic regression model. We applied Cordell's method as implemented in the R package TRIO to test for possible interactions. While no SNPs showed evidence of linkage and association with NSCL/P after Bonferroni correction, we found signals of G × G interactions between SNPs in 16p13.3. Nine pairs of SNP-SNP interactions attained significance after Bonferroni correction, among which the most significant interaction was found between rs2072346 (ADCY9) and rs11646137 (intergenic region, P = 7.2 × 10

Indexed as

Genetic Predisposition to DiseaseBrainChromosomes, Human, Pair 16Cleft LipCleft PalateEpistasis, GeneticGenome-Wide Association StudyHaplotypesHumansLinkage DisequilibriumPolymorphism, Single NucleotideRisk Factorscase-parent triosgene-gene interactiongenome-wide association studynon-syndromic cleft lip with or without cleft palate

Identifiers

PMID28402597
PMCPMC5559727
OpenAlexW2607375323

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.