ArticleGenome biology and evolution2017
The Relationship between Selection, Network Connectivity, and Regulatory Variation within a Population of Capsella grandiflora.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
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- Gene expression evolution is predicted by stronger indirect selection at more pleiotropic genes.Evolution letters · 2025Article
- Flexibility in Gene Coexpression at Developmental and Evolutionary Timescales.Molecular biology and evolution · 2025Article
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- Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation.eLife · 2025Article
- Polygenic selection to a changing optimum under self-fertilisation.PLoS genetics · 2024Article
- A multi-level approach reveals key physiological and molecular traits in the response of two rice genotypes subjected to water deficit at the reproductive stage.Plant-environment interactions (Hoboken, N.J.) · 2023Review
- The role of gene presence-absence variations on genetic incompatibility in Asian rice.The New phytologist · 2023Article
- Weaker selection on genes with treatment-specific expression consistent with a limit on plasticity evolution in Arabidopsis thaliana.Genetics · 2023Article
- Weak gene-gene interaction facilitates the evolution of gene expression plasticity.BMC biology · 2023Article
- Deleterious Mutations and the Rare Allele Burden on Rice Gene Expression.Molecular biology and evolution · 2022Article
- Globally Relaxed Selection and Local Adaptation in Boechera stricta.Genome biology and evolution · 2022Article
- Selection on Accessible Chromatin Regions in Capsella grandiflora.Molecular biology and evolution · 2021Article
- Multi-locus interactions and the build-up of reproductive isolation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Biased Gene Conversion Constrains Adaptation inGenetics · 2020Article
- Gene expression predictions and networks in natural populations supports the omnigenic theory.BMC genomics · 2020Article
- A Similar Genetic Architecture Underlies the Convergent Evolution of the Selfing Syndrome inThe Plant cell · 2020Article
- Pleiotropy facilitates local adaptation to distant optima in common ragweed (Ambrosia artemisiifolia).PLoS genetics · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions between genes can have important consequences for how selection shapes sequence variation at these genes. Specifically, genes that have pleiotropic effects by affecting the expression level of many other genes may be under stronger selective constraint. We used coexpression networks to measure connectivity between genes and investigated the relationship between gene connectivity and selection in a natural population of the plant Capsella grandiflora. We observed that network connectivity was negatively correlated with genetic divergence due to stronger negative selection on highly-connected genes even when controlling for variation in gene expression level. However, the presence of local regulatory variation for a gene's expression level was also associated with reduced negative selection and lower gene connectivity. While it is difficult to disentangle the causal relationships between these factors, our results show that both connectivity and local regulatory variation are important factors for explaining variation in selection between genes.
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