ArticleEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2017
Growth patterns of pulmonary metastases: should we adjust resection techniques to primary histology and size?
Article in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Laser-assisted lung metastasectomy: a systematic review.Updates in surgery · 2023Pooled it
- Article
- [When and how are pulmonary metastases surgically treated in sarcomas?]Chirurgie (Heidelberg, Germany) · 2026Review
- What we can learn from the lepidic growth pattern of pulmonary metastases.Clinical & experimental metastasis · 2026Review
- Article
- Article
- Recurrence-free survival curve for pulmonary metastasectomy in colorectal cancer plateaus at 3 years.Updates in surgery · 2024Article
- Laser assisted pulmonary metastasectomy promises a low local recurrence rate.Scientific reports · 2024Article
- Prognostic Impact of Visceral Pleural Invasion in Resected Solitary Lung Metastases from Gastric Cancer.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2023Article
- Lung nodule in patients with extrathoracic primary cancer-not always what it seems.Journal of thoracic disease · 2023Article
- More is more in pulmonary metastasectomy?Journal of thoracic disease · 2022Article
- Anatomical resection of colorectal lung metastases: a reasonable indication without evidence-non-systematic and incomplete reporting is a key issue.Journal of thoracic disease · 2022Article
- The extent of pulmonary resection for lung metastases from colorectal cancer.Journal of thoracic disease · 2022Article
- Impact of the extent of lung resection on postoperative outcomes of pulmonary metastasectomy for colorectal cancer metastases: an exploratory systematic review.Journal of thoracic disease · 2022Review
- Local Effects of a 1940 nm Thulium-Doped Fiber Laser and a 1470 nm Diode Laser on the Pulmonary Parenchyma: An Experimental Study in a Pig Model.Materials (Basel, Switzerland) · 2021Article
- Prospective study of recurrence at the surgical margin after wedge resection of pulmonary metastases.General thoracic and cardiovascular surgery · 2021Article
- Preoperative evaluation and indications for pulmonary metastasectomy.Journal of thoracic disease · 2021Review
- Lymphadenectomy in pulmonary metastasectomy.Journal of thoracic disease · 2021Review
- The Tumor Microenvironment in Liver Metastases from Colorectal Carcinoma in the Context of the Histologic Growth Patterns.International journal of molecular sciences · 2021Review
- Differentiation of primary lung cancer from solitary lung metastasis in patients with colorectal cancer: a retrospective cohort study.World journal of surgical oncology · 2021Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSafety margins in pulmonary metastasectomy are not yet well defined. We hypothesize that histological subtype, size of the lesion and local growth characteristics must be taken into consideration during metastasectomy. This study was conducted to examine and classify growth patterns at resection margins and define the relationships between aggressive local growth, metastasis size and local recurrence to direct metastasectomy.
methodsHistologic sections of pulmonary metastases were prospectively collected and haematoxylin-eosin stains were systematically evaluated and classified by their pattern of lung tissue infiltration. Logistic regression was used to model the association between the subgroups of colorectal, renal cell and epithelial cancers and melanomas and sarcomas.
resultsFrom 183 patients, 412 lung specimens were removed, which contained 459 pulmonary metastases. We found that 58% of all lesions had microscopic signs of aggressive local dissemination. The metastases showed histology-specific patterns of local growth: sarcoma was associated with pleural infiltration; colorectal metastases with interstitial spread and aerogenous spread of floating cancer cell clusters; and melanoma with perivascular growth and with lymph vessel involvement. Aggressive patterns of growth had an increasing probability of around 3% for each additional millimetre of metastasis diameter. Local intrapulmonary recurrence was significantly more common in association with interstitial growth and pleural penetration as well as safety margins <7 mm.
conclusionsApproximately 40% of all lung metastases have a smooth surface and might be resected with small margins. Growth characteristics within the lung differ with the histologic subtype and safety margins should generally increase with the size of the metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.