ArticleScientific reports2017
Prevalence of Modic changes in the lumbar vertebrae and their associations with workload, smoking and weight in northern China.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Incidence and risk factors for modic changes in the lumbar spine: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- The association between occupational loading and spine degeneration on imaging - a systematic review and meta-analysis.BMC musculoskeletal disorders · 2019Pooled it
- Association of Modic change types and their short tau inversion recovery signals with clinical characteristics- a cross sectional study of chronic low back pain patients in the AIM-study.BMC musculoskeletal disorders · 2020Trial
- Modic changes, chronic low back pain, and lifestyle and mental health factors: a cross-sectional analysis of a cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Causal association of education, smoking, sedentary lifestyle and body mass index with disc degeneration: Mendelian randomization.Medicine · 2025Article
- The Impact of Diabetes Mellitus on Patient-Reported Outcomes of Chronic Low Back Pain with Modic Changes at One Year: A Prospective Cohort Study.Global spine journal · 2025Article
- Gut microbiome dysbiosis implicates the gut-bone axis in Modic changes: a metagenomic case-control study.Frontiers in microbiology · 2025Article
- SMOKING AND MODIC CHANGES IN PATIENTS WITH CHRONIC LOW BACK PAIN: A COMPARATIVE STUDY.Acta ortopedica brasileira · 2024Article
- Study and analysis of the correlation between lumbar spondylolisthesis and Modic changes.Frontiers in surgery · 2024Article
- Do Modic changes contribute to lumbar instability or other way around? A retrospective study based on their types, extents, and affected lumbar segments.BMC musculoskeletal disorders · 2023Article
- Modic change is associated with increased BMI but not autoimmune diseases in TwinsUK.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Asymmetric distribution of Modic changes in patients with lumbar disc herniation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Identification of a potential novel biomarker in intervertebral disk degeneration by bioinformatics analysis and experimental validation.Frontiers in immunology · 2023Article
- Smoking and degenerative spinal disease: A systematic review.Brain & spine · 2022Review
- Basivertebral Nerve Ablation for the Treatment of Vertebrogenic Pain.Pain and therapy · 2021Review
- Association between device-measured physical activity and lumbar Modic changes.BMC musculoskeletal disorders · 2020Article
- Modic changes of the lumbar spine-their association with the lumbar sagittal parameters: A retrospective imaging study.Journal of orthopaedic surgery and research · 2020Article
- Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes).International journal of molecular sciences · 2020Article
- Intervertebral disc degeneration in mice with type II diabetes induced by leptin receptor deficiency.BMC musculoskeletal disorders · 2020Article
- Vertebral Bone Marrow Heterogeneity Using Texture Analysis of Chemical Shift Encoding-Based MRI: Variations in Age, Sex, and Anatomical Location.Frontiers in endocrinology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of Modic changes (MCs) in the lumbar endplates and the evaluation of the relationships between MCs and risk factors are vital for research into MCs. The T1-weighted and T2-weighted sagittal MRI scans of 210 patients who exhibited lumbar intervertebral disc degeneration were retrospectively reviewed. The patients' weights, genders, smoking statuses, physical activity levels and specific types of MC were recorded. The associations between MCs and risk factors, such as physical work, smoking and body mass index, were also analysed. MCs were observed in 47 patients (22.4%), including 16 males and 31 females. Among all patients, the L5/S1 lumbar level was most likely to suffer MCs. The MCs were predominantly type II. MCs occurred more often in obese patients than in normal and overweight patients (P < 0.05). Patients whose jobs required heavy labour were more likely to develop MCs (P < 0.05). Heavy work and obesity were related to type III MCs more strongly than the other types (P > 0.05). Smoking seemed not to be correlated with the incidence of MCs (P > 0.05). Gender, obesity and heavy work were strongly associated with MCs. Biomechanical factors may play a critical role in the development of MCs.
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