ArticlePhysics in medicine and biology2017
Longitudinal optical monitoring of blood flow in breast tumors during neoadjuvant chemotherapy.
Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Effects of exercise training on calf muscle oxygen extraction and blood flow in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Multimodal imaging and artificial intelligence for response assessment to neoadjuvant therapy in breast cancer: a comprehensive review.NPJ breast cancer · 2026Review
- Comparison of diffuse correlation spectroscopy, interferometric diffusing wave spectroscopy, and speckle contrast optical spectroscopy for blood flow monitoring.Neurophotonics · 2025Article
- Prediction of the response to antiangiogenic sunitinib therapy by non-invasive hybrid diffuse optics in renal cell carcinoma.Biomedical optics express · 2024Article
- A Device-on-Chip Solution for Real-Time Diffuse Correlation Spectroscopy Using FPGA.Biosensors · 2024Article
- Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury.Biomedical optics express · 2023Article
- Evaluation of SLE arthritis using frequency domain optical imaging.Lupus science & medicine · 2021Article
- Recipes for diffuse correlation spectroscopy instrument design using commonly utilized hardware based on targets for signal-to-noise ratio and precision.Biomedical optics express · 2021Article
- Blood Flow Measurements Enable Optimization of Light Delivery for Personalized Photodynamic Therapy.Cancers · 2020Article
- Diffuse optical spectroscopic imaging reveals distinct early breast tumor hemodynamic responses to metronomic and maximum tolerated dose regimens.Breast cancer research : BCR · 2020Article
- Diffuse Correlation Spectroscopy Analysis Implemented on a Field Programmable Gate Array.IEEE access : practical innovations, open solutions · 2019Article
- Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.Journal of biomedical optics · 2019Article
- Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment.Journal of biomedical optics · 2018Article
- Detection of precancerous lesions in the oral cavity using oblique polarized reflectance spectroscopy: a clinical feasibility study.Journal of biomedical optics · 2017Article
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Authors and funding
9 authors.
Funding
Abstract
We measure tissue blood flow markers in breast tumors during neoadjuvant chemotherapy and investigate their correlation to pathologic complete response in a pilot longitudinal patient study (n = 4). Tumor blood flow is quantified optically by diffuse correlation spectroscopy (DCS), and tissue optical properties, blood oxygen saturation, and total hemoglobin concentration are derived from concurrent diffuse optical spectroscopic imaging (DOSI). The study represents the first longitudinal DCS measurement of neoadjuvant chemotherapy in humans over the entire course of treatment; it therefore offers a first correlation between DCS flow indices and pathologic complete response. The use of absolute optical properties measured by DOSI facilitates significant improvement of DCS blood flow calculation, which typically assumes optical properties based on literature values. Additionally, the combination of the DCS blood flow index and the tissue oxygen saturation from DOSI permits investigation of tissue oxygen metabolism. Pilot results from four patients suggest that lower blood flow in the lesion-bearing breast is correlated with pathologic complete response. Both absolute lesion blood flow and lesion flow relative to the contralateral breast exhibit potential for characterization of pathological response. This initial demonstration of the combined optical approach for chemotherapy monitoring provides incentive for more comprehensive studies in the future and can help power those investigations.
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