Evidence map›Paper›PMID 28402265›Full record

ArticleOncotarget2017

Systematic comparison of biologically active foreign ions-codoped calcium phosphate microparticles on osteogenic differentiation in rat osteoporotic and normal mesenchymal stem cells.

Xiao-Yi Chen, San-Zhong Xu, Xuan-Wei Wang, Xian-Yan Yang, Liang Ma, Lei Zhang, Guo-Jing Yang, Fan Yang, Lin-Hong Wang, Xin-Li Zhang and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Xiao-Yi ChenClinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
San-Zhong XuThe First Affiliated Hospital, School of Medicine of Zhejiang University, Hangzhou 310009, China.
Xuan-Wei WangThe First Affiliated Hospital, School of Medicine of Zhejiang University, Hangzhou 310009, China.
Xian-Yan YangZhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou 310058, China.
Liang MaZhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou 310058, China.
Lei ZhangRui'an People's Hospital & The 3rd Affiliated Hospital to Wenzhou Medical University, Rui'an 325005, China.
Guo-Jing YangRui'an People's Hospital & The 3rd Affiliated Hospital to Wenzhou Medical University, Rui'an 325005, China.
Fan YangClinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Lin-Hong WangClinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Xin-Li ZhangDental and Craniofacial Research Institute, School of Dentistry, University of California, Los Angeles, CA 90095, USA.
Kang TingDental and Craniofacial Research Institute, School of Dentistry, University of California, Los Angeles, CA 90095, USA.
Chang-You GaoZhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou 310058, China.
Xiao-Zhou MouClinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Zhong-Ru GouZhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou 310058, China.
Hai ZouDepartment of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Zhejiang University · CNZhejiang Provincial People's Hospital · CNUniversity of California, Los Angeles · USRuian People's Hospital · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis is a disease characterized by structural deterioration of bone tissue, leading to skeletal fragility with increased fracture risk. Calcium phosphates (CaPs) are widely used in bone tissue engineering strategies as they have similarities to bone apatite except for the absence of trace elements (TEs) in the CaPs. Bioactive glasses (BGs) have also been used successfully in clinic for craniomaxillofacial and dental applications during the last two decades due to their excellent potential for bonding with bone and inducing osteoblastic differentiation. In this study, we evaluated the osteogenic effects of the ionic dissolution products of the quaternary Si-Sr-Zn-Mg-codoped CaP (TEs-CaP) or 45S5 Bioglass® (45S5 BG), both as mixtures and separately, on rat bone marrow-derived mesenchymal stem cells (rOMSCs & rMSCs) from osteoporotic and normal animals, using an MTT test and Alizarin Red S staining. The materials enhanced cell proliferation and osteogenic differentiation, especially the combination of the BG and TEs-CaP. Analysis by quantitative PCR and ELISA indicated that the expression of osteogenic-specific genes and proteins were elevated. These investigations suggest that the TEs-CaP and 45S5 BG operate synergistically to create an extracellular environment that promotes proliferation and terminal osteogenic differentiation of both osteoporotic and normal rMSCs.

Indexed as

IonsAlkaline PhosphataseAnimalsCalcification, PhysiologicCalcium PhosphatesCell DifferentiationCell ProliferationCells, CulturedDisease Models, AnimalFemaleGene Expression ProfilingGene Expression RegulationMesenchymal Stem CellsOsteogenesisOsteoporosisRatsAlkaline Phosphatasecalcium phosphateCalcium PhosphatesIonsmicroparticlesmineral micronutrientsosteogenic differentiationrMSCsrOMSCs

Identifiers

PMID28402265
PMCPMC5482678
OpenAlexW2599305511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.