Evidence map›Paper›PMID 28402243›Full record

ArticleThe New England journal of medicine2017

Use of the National Heart, Lung, and Blood Institute Data Repository.

Sean A Coady, George A Mensah, Elizabeth L Wagner, Miriam E Goldfarb, Denise M Hitchcock, Carol A Giffen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New England journal of medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Trial
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  13. Observational
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  17. The ARIC (Atherosclerosis Risk In Communities) Study: JACC Focus Seminar 3/8.Journal of the American College of Cardiology · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sean A CoadyFrom the Division of Cardiovascular Sciences (S.A.C.), the Center for Translation Research and Implementation Science (G.A.M.), and the Division of Blood Diseases and Resources (E.L.W.), National Heart, Lung, and Blood Institute, Bethesda, and Information Management Services, Calverton (M.E.G., D.M.H., C.A.G.) - both in Maryland.
George A MensahFrom the Division of Cardiovascular Sciences (S.A.C.), the Center for Translation Research and Implementation Science (G.A.M.), and the Division of Blood Diseases and Resources (E.L.W.), National Heart, Lung, and Blood Institute, Bethesda, and Information Management Services, Calverton (M.E.G., D.M.H., C.A.G.) - both in Maryland.
Elizabeth L WagnerFrom the Division of Cardiovascular Sciences (S.A.C.), the Center for Translation Research and Implementation Science (G.A.M.), and the Division of Blood Diseases and Resources (E.L.W.), National Heart, Lung, and Blood Institute, Bethesda, and Information Management Services, Calverton (M.E.G., D.M.H., C.A.G.) - both in Maryland.
Miriam E GoldfarbFrom the Division of Cardiovascular Sciences (S.A.C.), the Center for Translation Research and Implementation Science (G.A.M.), and the Division of Blood Diseases and Resources (E.L.W.), National Heart, Lung, and Blood Institute, Bethesda, and Information Management Services, Calverton (M.E.G., D.M.H., C.A.G.) - both in Maryland.
Denise M HitchcockFrom the Division of Cardiovascular Sciences (S.A.C.), the Center for Translation Research and Implementation Science (G.A.M.), and the Division of Blood Diseases and Resources (E.L.W.), National Heart, Lung, and Blood Institute, Bethesda, and Information Management Services, Calverton (M.E.G., D.M.H., C.A.G.) - both in Maryland.
Carol A GiffenFrom the Division of Cardiovascular Sciences (S.A.C.), the Center for Translation Research and Implementation Science (G.A.M.), and the Division of Blood Diseases and Resources (E.L.W.), National Heart, Lung, and Blood Institute, Bethesda, and Information Management Services, Calverton (M.E.G., D.M.H., C.A.G.) - both in Maryland.

Funding

Intramural NIH HHS Z99 HL999999
6 · The paper itself

Abstract

backgroundResearch on data sharing from clinical trials has focused on elucidating perceptions, barriers, and attitudes among trialists and study participants with respect to sharing data. However, little information exists regarding utilization or associated publication of articles once clinical trial data have been widely shared.

methodsWe analyzed administrative records of investigator requests for data access, linked publications, and bibliometrics to describe the use of the National Heart, Lung, and Blood Institute data repository.

resultsFrom January 2000 through May 2016, a total of 370 investigators requested data from 1 or more clinical trials. Requests for trial data have been increasing, with 195 investigators (53%) initiating requests during the last 4.4 years of the study period. The predominant reason for requesting data was post hoc secondary analysis of new questions (72%), followed by analytic or statistical approaches to clinical trials (9%) and meta-analyses or pooled study research (7%). Of 172 requests with online project descriptions, only 2 requests were initiated for reanalysis of primary-outcome findings. Data from 88 of 100 available clinical trials were requested at least once, and the median time from repository availability to first request was 235 days. A total of 277 articles were published on the basis of data from 47 trials. Citation metrics from 224 articles indicated that half of the publications have cumulative citations that rank in the top 34% normalized for subject category and year of publication.

conclusionsDemand for trial data for secondary analysis has been increasing. Requesting data for the a priori purpose of reanalysis or verification of original findings was rare.

Indexed as

Clinical Trials as TopicInformation DisseminationNational Heart, Lung, and Blood Institute (U.S.)BibliometricsDatasets as TopicHumansKaplan-Meier EstimateObservational Studies as TopicPeriodicals as TopicUnited States

Identifiers

PMID28402243
PMCPMC5665376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.