Evidence map›Paper›PMID 28402213›Full record

ArticleRNA biology2017

Engineering and expressing circular RNAs via tRNA splicing.

John J Noto, Casey A Schmidt, A Gregory Matera

Abstract read
In one paragraph

Article in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Circular RNA as a Potential Biomarker for Melanoma: A Systematic Review.Frontiers in cell and developmental biology · 2021
    Pooled it
  3. Review
  4. Review
  5. Circular RNAs: key players in tumor immune evasion.Molecular and cellular biochemistry · 2025
    Review
  6. The Emerging Roles of CircPVT1 in Cancer Progression.Current pharmaceutical biotechnology · 2025
    Review
  7. Circular RNAs in Liver Diseases.Advances in experimental medicine and biology · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Overview of mJournal of cancer research and clinical oncology · 2023
    Review
  18. tRNARNA (New York, N.Y.) · 2023
    Article
  19. CircRNAs: emerging factors for regulating glucose metabolism in colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John J Notoa Curriculum in Genetics and Molecular Biology , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
Casey A Schmidta Curriculum in Genetics and Molecular Biology , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
A Gregory Materaa Curriculum in Genetics and Molecular Biology , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.ORCID 0000-0002-6406-0630

Funding

In vivo models of small RNP biogenesis and Spinal Muscular AtrophyR01GM118636 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MATERA, A. GREGORY · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM118636
6 · The paper itself

Abstract

Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with regulated expression and evolutionarily conserved functions. There are several mechanisms by which RNA circularization can occur in vivo. Here, we focus on the biogenesis of tRNA intronic circular RNAs (tricRNAs) in archaea and animals, and we detail their use as research tools for orthogonal, directed circRNA expression in vivo.

Indexed as

RNA Splice SitesRNA SplicingAnimalsAptamers, NucleotideArchaeaDrosophila melanogasterExonsGenetic EngineeringHEK293 CellsHeLa CellsHumansIntronsMiceRNARNA, CircularRNA PrecursorsAptamers, NucleotideRNARNA, CircularRNA PrecursorsRNA Splice SitesRNA, TransferBack-splicingcircRNAectopic gene expressionRNA aptamerstricRNAtRNA processing

Identifiers

PMID28402213
PMCPMC5680671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.