ArticleAnalytical chemistry2017
Patient-Derived Airway Secretion Dissociation Technique To Isolate and Concentrate Immune Cells Using Closed-Loop Inertial Microfluidics.
Article in Analytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Separation of Activated T Cells Using Multidimensional Double Spiral (MDDS) Inertial Microfluidics for High-Efficiency CAR T Cell Manufacturing.Analytical chemistry · 2024Article
- Blood component separation in straight microfluidic channels.Biomicrofluidics · 2023Article
- Multi-dimensional-double-spiral (MDDS) inertial microfluidic platform for sperm isolation directly from the raw semen sample.Scientific reports · 2022Article
- High-Throughput Cell Concentration Using A Piezoelectric Pump in Closed-Loop Viscoelastic Microfluidics.Micromachines · 2021Article
- Inertial Microfluidics Enabling Clinical Research.Micromachines · 2021Review
- Fully-automated and field-deployable blood leukocyte separation platform using multi-dimensional double spiral (MDDS) inertial microfluidics.Lab on a chip · 2020Article
- Advances in passively driven microfluidics and lab-on-chip devices: a comprehensive literature review and patent analysis.RSC advances · 2020Review
- Leukocyte function assessed via serial microlitre sampling of peripheral blood from sepsis patients correlates with disease severity.Nature biomedical engineering · 2019Article
- Experimental and numerical study of elasto-inertial focusing in straight channels.Biomicrofluidics · 2019Article
- Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA.Scientific reports · 2019Article
- Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics.Journal of visualized experiments : JoVE · 2018Article
- Negative Selection by Spiral Inertial Microfluidics Improves Viral Recovery and Sequencing from Blood.Analytical chemistry · 2018Article
- Thrombospondin-1 protects against pathogen-induced lung injury by limiting extracellular matrix proteolysis.JCI insight · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Assessment of airway secretion cells, both for research and clinical purposes, is a highly desired goal in patients with acute and chronic pulmonary diseases. However, lack of proper cell isolation and enrichment techniques hinder downstream evaluation and characterization of cells found in airway secretions. Here, we demonstrate a novel enrichment method to capture immune-related cells from clinical airway secretions using closed-loop separation of spiral inertial microfluidics (C-sep). By recirculating the output focusing stream back to the input reservoir and running continuously with a high flow processing rate, one can achieve optimal concentration, recovery and purity of airway immune cells from a large volume of diluent, which was not readily possible in the single-pass operation. Our method reproducibly recovers 94.0% of polymorphonuclear leukocytes (PMNs), with up to 10
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