ArticleDevelopment and psychopathology2017
Caregiver maltreatment causes altered neuronal DNA methylation in female rodents.
Article in Development and psychopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- How Early Life Stress Impact Maternal Care: A Systematic Review of Rodent Studies.Frontiers in behavioral neuroscience · 2019Pooled it
- From maintenance to modulation: Rethinking the role of DNA methyltransferase 1 in neuronal development.Neural regeneration research · 2026Article
- Neurodevelopmental effects of early life stress: PFC and cognition.Neuroscience and biobehavioral reviews · 2026Review
- Effects of Early Life Scarcity-Adversity on Maturational Milestones in Male and Female Rats.Developmental psychobiology · 2024Article
- The role of epigenetic mechanisms in the long-term effects of early-life adversity and mother-infant relationship on physiology and behavior of offspring in laboratory rats and mice.Developmental psychobiology · 2024Review
- Early Life Stress AffectsInternational journal of molecular sciences · 2022Review
- Cell-type-specific epigenetic effects of early life stress on the brain.Translational psychiatry · 2022Review
- Evaluating the challenges and reproducibility of studies investigating DNA methylation signatures of psychological stress.Epigenomics · 2022Review
- Neonatal resource scarcity alters maternal care and impacts offspring core temperature and growth in rats.Developmental psychobiology · 2021Article
- The effects of early-life immune activation on microglia-mediated neuronal remodeling and the associated ontogeny of hippocampal-dependent learning in juvenile rats.Brain, behavior, and immunity · 2021Article
- Glucocorticoid Signaling and Epigenetic Alterations in Stress-Related Disorders.International journal of molecular sciences · 2021Review
- Article
- The morphological characteristics of the physically abused child. Report of a case and literature review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie · 2020Review
- Preventing epigenetic traces of caregiver maltreatment: A role for HDAC inhibition.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Article
- DNA methylation and behavioral changes induced by neonatal spinal transection.Infant behavior & development · 2019Article
- BDNF genetic variants and methylation: effects on cognition in major depressive disorder.Translational psychiatry · 2019Article
- Female pups receive more maltreatment from stressed dams.Developmental psychobiology · 2019Article
- Pharmacological manipulation of DNA methylation normalizes maternal behavior, DNA methylation, and gene expression in dams with a history of maltreatment.Scientific reports · 2019Article
- Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity.Developmental psychobiology · 2019Review
- Changes in neuroplasticity following early-life social adversities: the possible role of brain-derived neurotrophic factor.Pediatric research · 2019Review
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Negative experiences with a caregiver during infancy can result in long-term changes in brain function and behavior, but underlying mechanisms are not well understood. It is our central hypothesis that brain and behavior changes are conferred by early childhood adversity through epigenetic changes involving DNA methylation. Using a rodent model of early-life caregiver maltreatment (involving exposure to an adverse caregiving environment for postnatal days 1-7), we have previously demonstrated abnormal methylation of DNA associated with the brain-derived neurotrophic factor (Bdnf) gene in the medial prefrontal cortex (mPFC) of adult rats. The aim of the current study was to characterize Bdnf DNA methylation in specific cell populations within the mPFC. In the prefrontal cortex, there is approximately twice as many neurons as glia, and studies have recently shown differential and distinctive DNA methylation patterns in neurons versus nonneurons. Here, we extracted nuclei from the mPFC of adult animals that had experienced maltreatment and used fluorescence-activated cell sorting to isolate cell types before performing bisulfite sequencing to estimate methylation of cytosine-guanine sites. Our data indicate that early-life stress induced methylation of DNA associated with Bdnf IV in a cell-type and sex-specific manner. Specifically, females that experienced early-life maltreatment exhibited greater neuronal cytosine-guanine methylation compared to controls, while no changes were detected in Bdnf methylation in males regardless of cell type. These changes localize the specificity of our previous findings to mPFC neurons and highlight the capacity of maltreatment to cause methylation changes that are likely to have functional consequences for neuronal function.
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