Evidence map›Paper›PMID 28401766›Full record

ArticleEnvironmental science & technology2017

Occurrence and In Vitro Bioactivity of Estrogen, Androgen, and Glucocorticoid Compounds in a Nationwide Screen of United States Stream Waters.

Justin M Conley, Nicola Evans, Mary C Cardon, Laura Rosenblum, Luke R Iwanowicz, Phillip C Hartig, Kathleen M Schenck, Paul M Bradley, Vickie S Wilson

Open access · greenAbstract read
In one paragraph

Article in Environmental science & technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 116 citations in OpenAlex.

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  13. Endocrine disruptors of sex hormone activities.Molecular and cellular endocrinology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Justin M ConleyU.S. Environmental Protection Agency/National Health and Environmental Effects Research Laboratory/Toxicity Assessment Division , Research Triangle Park, North Carolina 27711 United States.ORCID http://orcid.org/0000-0002-6622-5769
Nicola EvansU.S. Environmental Protection Agency/National Health and Environmental Effects Research Laboratory/Toxicity Assessment Division , Research Triangle Park, North Carolina 27711 United States.
Mary C CardonU.S. Environmental Protection Agency/National Health and Environmental Effects Research Laboratory/Toxicity Assessment Division , Research Triangle Park, North Carolina 27711 United States.
Laura RosenblumCB&I Federal Services , Cincinnati, Ohio 45212 United States.
Luke R IwanowiczU.S. Geological Survey/Leetown Science Center , Kearneysville, West Virginia 25430 United States.
Phillip C HartigU.S. Environmental Protection Agency/National Health and Environmental Effects Research Laboratory/Toxicity Assessment Division , Research Triangle Park, North Carolina 27711 United States.
Kathleen M SchenckU.S. Environmental Protection Agency/National Risk Management Research Laboratory/Water Supply and Water Resources Division , Cincinnati, Ohio 45220 United States.
Paul M BradleyU.S. Geological Survey/South Atlantic Water Science Center , Columbia, South Carolina 29210 United States.ORCID http://orcid.org/0000-0001-7522-8606
Vickie S WilsonU.S. Environmental Protection Agency/National Health and Environmental Effects Research Laboratory/Toxicity Assessment Division , Research Triangle Park, North Carolina 27711 United States.ORCID http://orcid.org/0000-0003-1661-8481
Environmental Protection Agency · USUnited States Geological Survey · US

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

In vitro bioassays are sensitive, effect-based tools used to quantitatively screen for chemicals with nuclear receptor activity in environmental samples. We measured in vitro estrogen (ER), androgen (AR), and glucocorticoid receptor (GR) activity, along with a broad suite of chemical analytes, in streamwater from 35 well-characterized sites (3 reference and 32 impacted) across 24 states and Puerto Rico. ER agonism was the most frequently detected with nearly all sites (34/35) displaying activity (range, 0.054-116 ng E2Eq L

Indexed as

GlucocorticoidsRiversBiological AssayEstrogensReceptors, EstrogenUnited StatesWater Pollutants, ChemicalEstrogensGlucocorticoidsReceptors, EstrogenWater Pollutants, Chemical

Identifiers

PMID28401766
PMCPMC11247474
OpenAlexW2606882354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.