Evidence map›Paper›PMID 28401605›Full record

Observational studyUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2018

Predicting delivery of a small-for-gestational-age infant and adverse perinatal outcome in women with suspected pre-eclampsia.

M Griffin, P T Seed, S Duckworth, R North, J Myers, L Mackillop, N Simpson, J Waugh, D Anumba, L C Kenny and 3 more

Abstract readMulticenter StudyObservational Study

PubMed Full text at PMC Publisher

In one paragraph

Observational study in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

12citing papers in PubMed, 1 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

Placental growth factor (PLGF)-based testing to help diagnose suspected pre-eclampsia: a systematic review and economic evaluation.Health technology assessment (Winchester, England) · 2026
Pooled it
Can placental growth factors explain birthweight variation in offspring of women with type 1 diabetes?Diabetologia · 2021
Trial
Joint Modeling of Birth Outcomes Using a Copula Distributional Regression Approach.Health economics · 2026
Article
The sFlt-1/PlGF Ratio at 12, 24, and 32 Weeks Gestation in Twin Pregnancies as a Predictor of Placental Dysfunction.Journal of clinical medicine · 2024
Article
Association between hypoproteinaemia with massive proteinuria and small for gestational age in pre-eclampsia: a single-centre, retrospective cohort study using propensity score matching.BMJ open · 2023
Article
Maternal Serum Angiogenic Profile and Its Correlations with Ultrasound Parameters and Perinatal Results in Normotensive and Preeclamptic Pregnancies Complicated by Fetal Growth Restriction.Journal of clinical medicine · 2023
Article
Perspectives on the Use of Placental Growth Factor (PlGF) in the Prediction and Diagnosis of Pre-Eclampsia: Recent Insights and Future Steps.International journal of women's health · 2023
Review
Tracking placental development in health and disease.Nature reviews. Endocrinology · 2020
Review
The ability of late pregnancy maternal tests to predict adverse pregnancy outcomes associated with placental dysfunction (specifically fetal growth restriction and pre-eclampsia): a protocol for a systematic review and meta-analysis of prognostic accuracy studies.Systematic reviews · 2020
Article
In vivo evidence of significant placental growth factor release by normal pregnancy placentas.Scientific reports · 2020
Article
Short-Term Prediction of Adverse Outcomes Using the sFlt-1 (Soluble fms-Like Tyrosine Kinase 1)/PlGF (Placental Growth Factor) Ratio in Asian Women With Suspected Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2019
Article
Fractional fetal thigh volume in the prediction of normal and abnormal fetal growth during the third trimester of pregnancy.American journal of obstetrics and gynecology · 2017
Article

4 · The record

Corrections and comments

Commented on by
Re: Predicting delivery of a small-for-gestational-age infant and adverse perinatal outcome in women with suspected pre-eclampsia. M. Griffin, P. T. Seed, S. Duckworth, R. North, J. Myers, L. Mackillop, N. Simpson, J. Waugh, D. Anumba, L. C. Kenny, C. W. G. Redman, A. H. Shennan and L. C. Chappell. Ultrasound Obstet Gynecol 2018; 51: 387-395.2018

5 · Who and what money

Authors and funding

13 authors.

M GriffinWomen's Health Academic Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5448-9513

P T SeedWomen's Health Academic Centre, King's College London, London, UK.

S DuckworthWomen's Health Academic Centre, King's College London, London, UK.

R NorthWomen's Health Academic Centre, King's College London, London, UK.

J MyersMaternal and Fetal Health Research Centre, University of Manchester, Manchester, UK.

L MackillopOxford University Hospital NHS Trust, Oxford, UK.

N SimpsonDivision of Women's and Children's Health, Faculty of Health, University of Leeds, Leeds, UK.

J WaughNewcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.

D AnumbaAcademic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, UK.

L C KennyINFANT Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland.

C W G RedmanNuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.

A H ShennanWomen's Health Academic Centre, King's College London, London, UK.

L C ChappellWomen's Health Academic Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6219-3379

Funding

Department of Health HTA/15/59/06Department of Health NIHR-CS-011-020Department of Health PB-PG-0214-33054Department of Health RP-2014-05-019

6 · The paper itself

Abstract

objectiveTo evaluate the test performance of 47 biomarkers and ultrasound parameters for the prediction of delivery of a small-for-gestational-age (SGA) infant and adverse perinatal outcome in women presenting with suspected pre-eclampsia.

methodsThis was a prospective, multicenter observational study in which 47 biomarkers and ultrasound parameters were measured in 397 women with a singleton pregnancy presenting with suspected preterm pre-eclampsia between 20 + 0 and 36 + 6 weeks' gestation, with the objective of evaluating them as predictors of subsequent delivery of a SGA infant and adverse perinatal outcome. Women with confirmed pre-eclampsia at enrollment were excluded. Factor analysis and stepwise logistic regression were performed in two prespecified groups stratified according to gestational age at enrollment. The primary outcome was delivery of a SGA infant with a birth weight < 3

resultsIn 274 women presenting at 20 + 0 to 34 + 6 weeks' gestation, 96 (35%) delivered a SGA-3 infant. For prediction of SGA-3, low maternal placental growth factor (PlGF) concentration had a sensitivity of 93% (95% CI, 84-98%) and negative predictive value (NPV) of 90% (95% CI, 76-97%) compared with a sensitivity of 71% (95% CI, 58-82%) and a NPV of 79% (95% CI, 68-87%) for ultrasound parameters (estimated fetal weight or abdominal circumference < 10

conclusionIn women presenting with suspected preterm pre-eclampsia, measurement of PlGF offers a useful adjunct for identifying those at high risk of delivering a SGA infant, allowing appropriate surveillance and timely intervention. © 2017 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.

Indexed as

Pre-EclampsiaUltrasonography, PrenatalAdultBirth WeightFemaleFetal Growth RetardationFetal WeightHumansInfant, NewbornInfant, Small for Gestational AgePredictive Value of TestsPregnancyPregnancy OutcomePregnancy ProteinsPregnancy Trimester, SecondPregnancy Trimester, ThirdPregnancy Proteinsgrowth restrictionplacental growth factorpre-eclampsiasmall-for-gestational-age

Identifiers

PMID28401605

DOI10.1002/uog.17490

PMCPMC5887913

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.