ArticleAMB Express2017
Metabolism and secretion of yellow pigment under high glucose stress with Monascus ruber.
Article in AMB Express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Exogenous glycine promoted the overproduction of extracellular pigments of Monascus purpureus S109 in submerged fermentation.Microbial cell factories · 2026Article
- Effects of L-cysteine on the synthesis and secretion of extracellular pigments in submerged fermentation ofFrontiers in microbiology · 2026Article
- Pigment Formation byJournal of agricultural and food chemistry · 2025Article
- Metabolomic Insights into the Promotional Effect of Mulberry Leaf Flavonoids on Monascus Fermentation for the Production of Pigments.Applied biochemistry and biotechnology · 2025Article
- Coordinated Synthesis of Pigments Differing in Side Chain Length inJournal of agricultural and food chemistry · 2025Article
- Isolation, identification, and production optimization of natural functional pigments produced byFrontiers in microbiology · 2025Article
- Mechanism of Inhibiting the Growth and Aflatoxin BToxins · 2023Article
- Solid-state fermentation of Saba banana peel for pigment production by Monascus purpureus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Comparative Transcriptomic and Metabolomic Analyses Reveal the Regulatory Effect and Mechanism of Tea Extracts on the Biosynthesis ofFoods (Basel, Switzerland) · 2022Article
- Increased Water-Soluble YellowFrontiers in microbiology · 2022Article
- Sodium starch octenyl succinate facilitated the production of water-soluble yellow pigments in Monascus ruber fermentation.Applied microbiology and biotechnology · 2021Article
- Inducing red pigment and inhibiting citrinin production by adding lanthanum(III) ion in Monascus purpureus fermentation.Applied microbiology and biotechnology · 2021Article
- Effect of initial pH, different nitrogen sources, and cultivation time on the production of yellow or orangeFood science & nutrition · 2019Article
- Post-treatment of Fungal Biomass to Enhance Pigment Production.Applied biochemistry and biotechnology · 2019Article
- Article
- Rising temperature stimulates the biosynthesis of water-soluble fluorescent yellow pigments and gene expression in Monascus ruber CGMCC10910.AMB Express · 2017Article
- Changing oxidoreduction potential to improve water-soluble yellow pigment production with Monascus ruber CGMCC 10910.Microbial cell factories · 2017Article
- Tracking of pigment accumulation and secretion in extractive fermentation of Monascus anka GIM 3.592.Microbial cell factories · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biosynthesis of microbial secondary metabolites is induced by a wide range of environmental stresses. In this study, submerged fermentation of Monascus yellow pigments by Monascus ruber CGMCC 10910 under high glucose stress was investigated. The increase of lipid content was the major contributor to the increase of dry cell weight (DCW), and the lipid-free DCW was only slightly changed under high glucose stress, which benefited the accumulation of intracellular hydrophobic pigments. The fatty acid composition analysis in Monascus cell membranes showed that high glucose stress significantly increased the ratio of unsaturated/saturated fatty acid and the index of unsaturated fatty acid (IUFA) value, which would improve the fluidity and permeability of the cell membrane. As a consequence, high glucose stress increased extracellular yellow pigments production by enhancing secretion and trans-membrane conversion of intracellular pigments to the broth. The total yield of extracellular and intracellular yellow pigments per unit of lipid-free DCW increased by 94.86 and 26.31% under high glucose stress compared to conventional fermentation, respectively. A real-time quantitative PCR analysis revealed that the expression of the pigment biosynthetic gene cluster was up-regulated under high glucose stress. The gene mppE, which is associated with yellow pigment biosynthesis, was significantly up-regulated. These results indicated that high glucose stress can shift the Monascus pigment biosynthesis pathway to accumulate yellow pigments and lead to a high yield of both extracellular and intracellular yellow pigments. These findings have potential application in commercial Monascus yellow pigment production.
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