Evidence map›Paper›PMID 28401484›Full record

ArticleMedical oncology (Northwood, London, England)2017

Vascular microinvasion from hepatocellular carcinoma: CT findings and pathologic correlation for the best therapeutic strategies.

Alfonso Reginelli, Angelo Vanzulli, Cristiano Sgrazzutti, Luca Caschera, Nicola Serra, Antonio Raucci, Fabrizio Urraro, Salvatore Cappabianca

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In one paragraph

Article in Medical oncology (Northwood, London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Colorectal cancer liver metastases: A radiologic point of view.World journal of gastrointestinal oncology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Peritoneal Carcinosis: What the Radiologist Needs to Know.Diagnostics (Basel, Switzerland) · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alfonso ReginelliDepartment of Internal and Experimental Medicine, Second University of Naples, Naples, Italy. alfonsoreginelli@hotmail.com.
Angelo VanzulliNiguarda Cancer Center - ASST Grande Ospedale Metropolitano, University of Milano, Niguarda, Milan, Italy.
Cristiano SgrazzuttiNiguarda Cancer Center - ASST Grande Ospedale Metropolitano, University of Milano, Niguarda, Milan, Italy.
Luca CascheraNiguarda Cancer Center - ASST Grande Ospedale Metropolitano, University of Milano, Niguarda, Milan, Italy.
Nicola SerraDepartment of Internal and Experimental Medicine, Second University of Naples, Naples, Italy.
Antonio RaucciDepartment of Internal and Experimental Medicine, Second University of Naples, Naples, Italy.
Fabrizio UrraroDepartment of Internal and Experimental Medicine, Second University of Naples, Naples, Italy.
Salvatore CappabiancaDepartment of Internal and Experimental Medicine, Second University of Naples, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrence of HCC reduces survival rates in patients treated with surgery, and one of the most relevant risk factors for tumour recurrence is microvascular invasion (mVI). The identification of mVI on preoperative examinations could improve surgical planning's and techniques so as to reduce the risk of tumour recurrence. During our study, we have revised 101 CT examinations of the liver performed on patients diagnosed with solitary HCC who had surgical treatment and pathological analysis of the specimens for mVI in order to detect CT signs which could be reliable in mVI prediction. On CT examinations, the tumours were evaluated for margins, capsule, size, contrast enhancement, halo sign and Thad. From our statistical analysis, we found out that irregularity in tumour margins and defects in peritumoural capsule are the most significant characteristics predicting mVI in HCC. Every report on CT examinations performed on surgical candidate patients should include suggestions about mVI probability in order to tailor procedures, reduce tumour recurrence risk and improve survival rates.

Indexed as

Carcinoma, HepatocellularFemaleHumansLiver NeoplasmsLogistic ModelsMaleMiddle AgedNeoplasm Recurrence, LocalTomography, X-Ray ComputedHepatocellular carcinomaLiver oncologyMicrovascular invasionMultidetector computed tomographyPatient’s outcomeTherapeutic strategy

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.