Evidence map›Paper›PMID 28401449›Full record

ArticlePathology oncology research : POR2018

Silence of Long Noncoding RNA NEAT1 Inhibits Malignant Biological Behaviors and Chemotherapy Resistance in Gastric Cancer.

Jiale Zhang, Bochao Zhao, Xiuxiu Chen, Zhenning Wang, Huimian Xu, Baojun Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Pathology oncology research : POR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 62 citations in OpenAlex.

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  11. Function of BCLAF1 in human disease.Oncology letters · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jiale ZhangDepartment of Surgical Oncology, Affiliated First Hospital, China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China.
Bochao ZhaoDepartment of Surgical Oncology, Affiliated First Hospital, China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China.
Xiuxiu ChenDepartment of Surgical Oncology, Affiliated First Hospital, China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China.
Zhenning WangDepartment of Surgical Oncology, Affiliated First Hospital, China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China.
Huimian XuDepartment of Surgical Oncology, Affiliated First Hospital, China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China.
Baojun HuangDepartment of Surgical Oncology, Affiliated First Hospital, China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, China. huang_bj@163.com.
China Medical University · CNFirst Hospital of China Medical University · CN

Funding

National Nature Science Foundation of China 81172408National Nature Science Foundation of China 81272716
6 · The paper itself

Abstract

Gastric cancer (GC) is the most common solid tumor in digestive system. Nuclear-enriched abundant transcript 1 (NEAT1) gene is a lncRNA, and reveal potential oncogene role in several malignant tumors. The aim of this study is to investigate the expression and clinical significance of Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) gene and its influence to malignant biologic behaviors and chemotherapy resistance to adriamycin in GC. This study found NEAT1 was up-regulated in GC tissues and cells, especially in in GC adriamycin-resistant cells. NEAT1 silence in SGC7901 cells could inhibit proliferation and invasion ability, and promote cell apoptosis significantly. NEAT1 silence in adriamycin-resistant SGC7901/ADR cells also depressed the half maximal inhibitory concentration (IC50) for adriamycin, chemotherapy resistance to adriamycin was inhibited significantly. NEAT1 knockdown promoted apoptosis in SGC7901/ADR cells induced by adriamycin. In summary, lncRNA NEAT1 is high-expressed in GC and functions as an oncogene to modulate apoptosis, invasion, proliferation and chemotherapy resistance of GC cells, which might be a novel potential therapeutic target for GC.

Indexed as

ApoptosisBiomarkers, TumorCell MovementCell ProliferationDoxorubicinDrug Resistance, NeoplasmHumansPrognosisRNA, Long NoncodingStomach NeoplasmsTumor Cells, CulturedUp-RegulationBiomarkers, TumorDoxorubicinNEAT1 long non-coding RNA, humanRNA, Long NoncodingChemotherapy resistanceGastric cancerLong noncoding RNAMalignant behaviorsNEAT1

Identifiers

PMID28401449
OpenAlexW2606264322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.