Evidence map›Paper›PMID 28401339›Full record

ArticleEuropean radiology2017

Evaluation of the R2* value in invasive ductal carcinoma with respect to hypoxic-related prognostic factors using iterative decomposition of water and fat with echo asymmetry and least-squares emission (IDEAL).

Mari Miyata, Takatoshi Aoki, Shohei Shimajiri, Atsuji Matsuyama, Shunsuke Kinoshita, Masami Fujii, Takefumi Katsuki, Yuzuru Inoue, Yoshika Nagata, Yuko Tashima and 1 more

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Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Mari MiyataDepartment of Radiology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Takatoshi AokiDepartment of Radiology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan. a-taka@med.uoeh-u.ac.jp.
Shohei ShimajiriDepartment of Pathology and Cell Biology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Atsuji MatsuyamaDepartment of Pathology and Oncology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Shunsuke KinoshitaDepartment of Radiology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Masami FujiiDepartment of Radiology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Takefumi KatsukiFirst Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yuzuru InoueFirst Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yoshika NagataSecond department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yuko TashimaSecond department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yukunori KorogiDepartment of Radiology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
University of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo correlate the R2* value obtained by iterative decomposition of water and fat with echo asymmetry and least-squares emission (IDEAL) with fibrotic focus (FF), microvessel density and hypoxic biomarker (HIF-1α) in breast carcinoma.

methodsForty-two patients who were diagnosed with invasive ductal carcinoma (IDC) of the breast underwent breast MRI including IDEAL before surgery. The entire region of interest (ROI) was delineated on the R2* map, and average tumour R2* value was calculated for each ROI. Histological specimens were evaluated for the presence of FF, the microvessel density (the average microvessel density and the ratio of peripheral to central microvessel density), and the grading of HIF-1α.

resultsFF was identified in 47.6% (20/42) of IDCs. Average R2* value for IDC with FF (42.4±13.2 Hz) was significantly higher than that without FF (28.5±13.9 Hz) (P = 0.01). Spearman rank correlation suggested that the average R2* value correlated with the grade of HIF-1α and the ratio of peripheral to central microvessel density for IDCs (P < 0.001).

conclusionQuantification of tumour R2* using IDEAL is associated with the presence of FF and the overexpression of HIF-1α, and may therefore be useful in predicting hypoxia of breast carcinoma. KEY POINTS: • R2* value obtained by IDEAL correlates with the overexpression of HIF-1α. • R2* value obtained by IDEAL is associated with fibrotic focus. • R2* quantification may be useful in predicting hypoxia of breast carcinoma.

Indexed as

Adipose TissueAdultAgedBiomarkers, TumorBreast NeoplasmsCarcinoma, DuctalFemaleFibrosisHumansHypoxia-Inducible Factor 1, alpha SubunitLeast-Squares AnalysisMagnetic Resonance ImagingPrognosisRetrospective StudiesWaterBiomarkers, TumorHypoxia-Inducible Factor 1, alpha SubunitWaterBreastBreast cancerHypoxic prognostic factorInvasive ductal carcinomaMRI

Identifiers

PMID28401339
OpenAlexW2605430042

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.