Evidence map›Paper›PMID 28401320›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2017

The virulence factors of group A streptococcus strains isolated from invasive and non-invasive infections in Polish and German centres, 2009-2011.

M Strus, P B Heczko, E Golińska, A Tomusiak, A Chmielarczyk, M Dorycka, M van der Linden, A Samet, A Piórkowska

Abstract readHistorical Article
PubMed Publisher
In one paragraph

Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Group aMicrobiology spectrum · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Molecular Characteristics ofFrontiers in microbiology · 2021
    Article
  7. Iranian journal of basic medical sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M StrusChair of Microbiology, Jagiellonian University Medical College, 18 Czysta Str, 31-121, Kracow, Poland.
P B HeczkoChair of Microbiology, Jagiellonian University Medical College, 18 Czysta Str, 31-121, Kracow, Poland.
E GolińskaChair of Microbiology, Jagiellonian University Medical College, 18 Czysta Str, 31-121, Kracow, Poland. edyta.golinska@uj.edu.pl.ORCID http://orcid.org/0000-0001-8612-8897
A TomusiakChair of Microbiology, Jagiellonian University Medical College, 18 Czysta Str, 31-121, Kracow, Poland.
A ChmielarczykChair of Microbiology, Jagiellonian University Medical College, 18 Czysta Str, 31-121, Kracow, Poland.
M DoryckaMicrobiological Laboratory, Diagnostics Inc. Krakow Branch, Na Skarpie 66 axis, 31-913, Kracow, Poland.
M van der LindenNational Reference Center for Streptococci, Department of Medical Microbiology, University Hospital (RWTH), Aachen, Germany.
A SametDepartment of Clinical Microbiology, University Clinical Center in Gdansk, 7 Debinki Str, 80-952, Gdansk, Poland.
A PiórkowskaDepartment of Clinical Microbiology, University Clinical Center in Gdansk, 7 Debinki Str, 80-952, Gdansk, Poland.

Funding

Jagiellonian University Medical College K/ZDS/005465National Science Centre Poland N N401618040
6 · The paper itself

Abstract

Streptococcus pyogenes (GAS) is one of the major human pathogenic bacteria that cause a wide range of diseases. Currently, increased incidence of streptococcal invasive infections is observed worldwide. In this study, we focused on the prevalence of genes encoding superantigens and type M proteins in the population of GAS strains from invasive versus non-invasive infections. We tested 253 GAS strains: 48 strains from patients with invasive infections (18 from wound/deep skin localization, 30 from women in labour) and 205 strains from non-invasive forms (147 from common infections of the upper respiratory, 49 from the vagina of females with genital tract infections and 9 from non-invasive wound and superficial skin infections). Significant differences were found in the occurrence of genes: speG, speI, speJ and smeZ, which were more common in GAS isolated from invasive than from non-invasive strains; speJ and smeZ occurred more frequently in strains from invasive perinatal infections versus strains from women without symptoms of invasive infection; speH and speI in strains from invasive skin/wound infection versus strains isolated from non-invasive wound and superficial skin infections. Emm types 1 and 12 predominated in the group of strains isolated from superficial infections and type 28 in those from puerperal fever. Occurrence of genes encoding virulence factors is common in genomic DNA of most of S. pyogenes, regardless whether these streptococcal infections are invasive or non-invasive. On the other hand, it appears that strains with speG, speI, speJ and smeZ genes may have a particular potential for virulence.

Indexed as

Antigens, BacterialBacterial Outer Membrane ProteinsCarrier ProteinsFemaleGenotypeHistory, 21st CenturyHumansMaleSerogroupStreptococcal InfectionsStreptococcus pyogenesVirulenceVirulence FactorsAntigens, BacterialBacterial Outer Membrane ProteinsCarrier Proteinsstreptococcal M proteinVirulence FactorsInvasive InfectionPuerperal FeverStreptococcal Pyrogenic ExotoxinStreptococcal Toxic Shock SyndromeSuperficial Skin Infection

Identifiers

PMID28401320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.